Oxygen Radical-Mediated Pulmonary Toxicity Induced by Some Cationic Liposomes

被引：0
作者：
Sujatha Dokka
David Toledo
Xianglin Shi
Vincent Castranova
Yon Rojanasakul
机构：
[1] West Virginia University,Department of Basic Pharmaceutical Sciences
[2] Rhone-Poulenc Rorer Central Research,Pathology and Physiology Research Branch
[3] National Institute for Occupational Safety and Health,Department of Basic Pharmaceutical Sciences
[4] West Virginia University,undefined
来源：
Pharmaceutical Research | 2000年 / 17卷
关键词：
cationic liposomes; charge; toxicity; reactive oxygen intermediates;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The objectives of this study are to investigate the toxicityassociated with polycationic liposomes and to elucidate the underlyingmechanism. We tested the hypothesis that the positive charge of liposomesis a key determinant of toxicity by testing differently chargedliposomes in mice.
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页码：521 / 525
页数：4
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