Oxygen Radical-Mediated Pulmonary Toxicity Induced by Some Cationic Liposomes

被引：0
作者：
Sujatha Dokka
David Toledo
Xianglin Shi
Vincent Castranova
Yon Rojanasakul
机构：
[1] West Virginia University,Department of Basic Pharmaceutical Sciences
[2] Rhone-Poulenc Rorer Central Research,Pathology and Physiology Research Branch
[3] National Institute for Occupational Safety and Health,Department of Basic Pharmaceutical Sciences
[4] West Virginia University,undefined
来源：
Pharmaceutical Research | 2000年 / 17卷
关键词：
cationic liposomes; charge; toxicity; reactive oxygen intermediates;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The objectives of this study are to investigate the toxicityassociated with polycationic liposomes and to elucidate the underlyingmechanism. We tested the hypothesis that the positive charge of liposomesis a key determinant of toxicity by testing differently chargedliposomes in mice.
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页码：521 / 525
页数：4
相关论文
共 86 条
[1]  
Gao X.(1995)Cationic liposome-mediated gene transfer Gene Ther. 2 710-722
[2]  
Huang L.(1991)A novel cationic liposome reagent for efficient transfection of mammalian cells Biochim. Biophys. Res. Commun. 179 280-285
[3]  
Gao X.(1989)In vivo transfection of expression of murine lungs with a functioning prokaryotic gene using a liposome vehicle Am. J. Med. Sci. 298 278-281
[4]  
Huang L.(1995)Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis Nature Med. 1 39-46
[5]  
Brigham K. L.(1993)Direct gene transfer with DNA-liposome complexes in melanoma: Expression, biologic activity, and lack of toxicity in humans Proc. Natl. Acad. Sci. USA 90 11307-11311
[6]  
Meyrick B.(1997)Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung Human Gene Ther. 8 689-707
[7]  
Christman B.(1998)Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: Cationic lipid complexes J. Immunol. 160 4580-4586
[8]  
Magnusson M.(1997)Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration Human Gene Ther. 8 1585-1594
[9]  
King G.(1996)Guanidium-cholesterol cationic lipids: efficient vectors for the transfection of eukaryotic cells Proc. Natl. Acad. Sci. USA 93 9682-9686
[10]  
Berry L.(1992)Inhibition of protein kinase C by cationic amphiphiles Biochemistry 31 9025-9030
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