Age-related differences in expression of signal differentiation factors for human thymic epithelial cells

被引：0

作者：

V. O. Polyakova

I. M. Kvetnoy

S. S. Konovalov

P. N. Zezulin

I. V. Knyazkin

机构：

[1] Northwestern Division of the Russian Academy of Medical Sciences,St. Petersburg Institute of Bioregulation and Gerontology

来源：

Bulletin of Experimental Biology and Medicine | 2007年 / 144卷

关键词：

thymus; aging; transcription factors; confocal microscopy;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Expression of transcription proteins PAX1, Hoxa3, and TLP regulating differentiation of thymic epithelial cells is detected in human thymus starting from gestation week 22 until the age of 95 years. Expression of transcription factors significantly decreased during aging. Apart from the decrease in the expression of signal differentiation factors in cultured thymic epithelial cells, proliferative activity of T lymphocytes cocultured with thymic epithelial cells also decreased in aging cultures, which demonstrated the important regulatory effect of transcription proteins on maturation and maintenance of T lymphocytes. Taking into account the important role of transcription proteins in the regulation of proliferation and function of T lymphocytes, whose number sharply decreases during aging, the maintenance of the level of expression of transcription factors during aging is a promising trend in modern biogerontology.

引用

页码：235 / 237

页数：2

共 50 条

[41] Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts [J].

Zhou, Shuanhu ;

Greenberger, Joel S. ;

Epperly, Michael W. ;

Goff, Julie P. ;

Adler, Carolyn ;

LeBoff, Meryl S. ;

Glowacki, Julie .

AGING CELL, 2008, 7 (03) :335-343

[42] Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly [J].

Ravaioli, Francesco ;

Bacalini, Maria G. ;

Franceschi, Claudio ;

Garagnani, Paolo .

GENES, 2018, 9 (01)

[43] Age-related differences in human corticospinal excitability during simple reaction time [J].

Levin, Oron ;

Cuypers, Koen ;

Netz, Yael ;

Thijs, Herbert ;

Nuttin, Bart ;

Helsen, Werner F. ;

Meesen, Raf L. J. .

NEUROSCIENCE LETTERS, 2011, 487 (01) :53-57

[44] Age-Related Differences in Rat Multipotent Mesenchymal Stromal Bone Marrow Cells [J].

M. P. Valyushina ;

L. B. Buravkova .

Bulletin of Experimental Biology and Medicine, 2013, 155 :129-133

[45] Age-Related Differences in Rat Multipotent Mesenchymal Stromal Bone Marrow Cells [J].

Valyushina, M. P. ;

Buravkova, L. B. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2013, 155 (01) :129-133

[46] Gene expression markers of age-related inflammation in two human cohorts [J].

Pilling, Luke C. ;

Joehanes, Roby ;

Melzer, David ;

Harries, Lorna W. ;

Henley, William ;

Dupuis, Josee ;

Lin, Honghuang ;

Mitchell, Marcus ;

Hernandez, Dena ;

Ying, Sai-Xia ;

Lunetta, Kathryn L. ;

Benjamin, Emelia J. ;

Singleton, Andrew ;

Levy, Daniel ;

Munson, Peter ;

Murabito, Joanne M. ;

Ferrucci, Luigi .

EXPERIMENTAL GERONTOLOGY, 2015, 70 :37-45

[47] Age-related differences in trunk intrinsic stiffness [J].

Vazirian, Milad ;

Shojaei, Iman ;

Tromp, Rebecca L. ;

Nussbaum, Maury A. ;

Bazrgari, Babak .

JOURNAL OF BIOMECHANICS, 2016, 49 (06) :926-932

[48] Age-related differences in communication and audience design [J].

Horton, William S. ;

Spieler, Daniel H. .

PSYCHOLOGY AND AGING, 2007, 22 (02) :281-290

[49] Age-related neural differences in affiliation and isolation [J].

Beadle, Janelle N. ;

Yoon, Carolyn ;

Gutchess, Angela H. .

COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE, 2012, 12 (02) :269-279

[50] Age-related neural differences in affiliation and isolation [J].

Janelle N. Beadle ;

Carolyn Yoon ;

Angela H. Gutchess .

Cognitive, Affective, & Behavioral Neuroscience, 2012, 12 :269-279

← 1 2 3 4 5 →