Age-related differences in expression of signal differentiation factors for human thymic epithelial cells

被引：0

作者：

V. O. Polyakova

I. M. Kvetnoy

S. S. Konovalov

P. N. Zezulin

I. V. Knyazkin

机构：

[1] Northwestern Division of the Russian Academy of Medical Sciences,St. Petersburg Institute of Bioregulation and Gerontology

来源：

Bulletin of Experimental Biology and Medicine | 2007年 / 144卷

关键词：

thymus; aging; transcription factors; confocal microscopy;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Expression of transcription proteins PAX1, Hoxa3, and TLP regulating differentiation of thymic epithelial cells is detected in human thymus starting from gestation week 22 until the age of 95 years. Expression of transcription factors significantly decreased during aging. Apart from the decrease in the expression of signal differentiation factors in cultured thymic epithelial cells, proliferative activity of T lymphocytes cocultured with thymic epithelial cells also decreased in aging cultures, which demonstrated the important regulatory effect of transcription proteins on maturation and maintenance of T lymphocytes. Taking into account the important role of transcription proteins in the regulation of proliferation and function of T lymphocytes, whose number sharply decreases during aging, the maintenance of the level of expression of transcription factors during aging is a promising trend in modern biogerontology.

引用

页码：235 / 237

页数：2

共 50 条

[11] Decline or improvement? Age-related differences in facial expression recognition [J].

Suzuki, Atsunobu ;

Hoshino, Takahiro ;

Shigemasu, Kazuo ;

Kawamura, Mitsuru .

BIOLOGICAL PSYCHOLOGY, 2007, 74 (01) :75-84

[12] The role of thymic epithelium in thymus development and age-related thymic involution [J].

Fujimori, Sayumi ;

Ohigashi, Izumi .

JOURNAL OF MEDICAL INVESTIGATION, 2024, 71 (1-2) :29-39

[13] Mechanical properties of the human hand digits: Age-related differences [J].

Park, Jaebum ;

Pazin, Nemanja ;

Friedman, Jason ;

Zatsiorsky, Vladimir M. ;

Latash, Mark L. .

CLINICAL BIOMECHANICS, 2014, 29 (02) :129-137

[14] Mechanical age-related differences in the human cadaveric annulus fibrosus [J].

Sinopoli, Sabrina I. ;

Whittal, Mitchel C. ;

Chow, Noah ;

Gregory, Diane E. .

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2025, 168

[15] Reversal of age-related thymic involution by an LHRH agonist in miniature swine [J].

Hirakata, Atsushi ;

Okumi, Masayoshi ;

Griesemer, Adam D. ;

Shimizu, Akira ;

Nobori, Shuji ;

Tena, Aseda ;

Moran, Shannon ;

Arn, Scott ;

Boyd, Richard L. ;

Sachs, David H. ;

Yamada, Kazuhiko .

TRANSPLANT IMMUNOLOGY, 2010, 24 (01) :76-81

[16] Age-related expression of TGF beta family receptors in human cumulus oophorus cells [J].

A. Ribeiro ;

C. Freitas ;

L. Matos ;

A. Gouveia ;

F. Gomes ;

J. L. Silva Carvalho ;

H. Almeida .

Journal of Assisted Reproduction and Genetics, 2017, 34 :1121-1129

[17] Age-related expression of TGF beta family receptors in human cumulus oophorus cells [J].

Ribeiro, A. ;

Freitas, C. ;

Matos, L. ;

Gouveia, A. ;

Gomes, F. ;

Silva Carvalho, J. L. ;

Almeida, H. .

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2017, 34 (09) :1121-1129

[18] Age-related differences in gene expression and pathway activation following heatstroke [J].

Gomez, Maria ;

Al Mahri, Saeed ;

Abdullah, Mashan ;

Malik, Shuja Shafi ;

Yezli, Saber ;

Yassin, Yara ;

Khan, Anas ;

Lehe, Cynthia ;

Mohammad, Sameer ;

Hoehndorf, Robert ;

Bouchama, Abderrezak .

PHYSIOLOGICAL GENOMICS, 2025, 57 (02) :65-79

[19] Age-Related Changes in Immune Cells of the Human Cochlea [J].

Noble, Kenyaria, V ;

Liu, Ting ;

Matthews, Lois J. ;

Schulte, Bradley A. ;

Lang, Hainan .

FRONTIERS IN NEUROLOGY, 2019, 10

[20] Cytokine modulation, oxidative stress and thymic dysfunctions: Role of age-related changes in the experimental Trypanosoma cruzi infection Check for updates Age-related thymic dysfunctions and Trypanosoma cruzi infection [J].

Colato, Rafaela Pravato ;

Brazao, Vania ;

do Vale, Gabriel Tavares ;

Santello, Fabricia Helena ;

Sampaio, Pedro Alexandre ;

Tirapelli, Carlos Renato ;

Pereira-da-Silva, Gabriela ;

Do Prado, Jose Clovis, Jr. .

CYTOKINE, 2018, 111 :88-96

← 1 2 3 4 5 →