Flavonoids as dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and in vitro studies

[1] Wang B(2021)Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets Signal Transduct Target Ther 6 94-1521

[2] Wu L(2019)Brief story on prostaglandins, inhibitors of their synthesis, hematopoiesis and acute radiation syndrome Molecules 24 4019-553

[3] Chen J(2014)Inflammation, cancer and oxidative lipoxygenase activity are intimately linked Cancers (Basel) 6 1500-460

[4] Hofer M(2013)Exhaled breath condensate eicosanoid levels associate with asthma and its severity J Allergy Clin Immunol 132 547-110s

[5] Hoferová Z(2014)Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis Arthritis Res Ther 16 496-10

[6] Falk M(2014)5-lipoxygenase inhibitors attenuate TNF-α-Induced inflammation in human synovial fibroblasts PLoS ONE 9 452-381

[7] Wisastra R(2017)Critical role of LTB 4/BLT1 in IL-23–induced synovial inflammation and osteoclastogenesis via NF-κB J Immunol 198 81s-1006

[8] Dekker FJ(2008)Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond J Pharm Pharm Sci 11 1-324

[9] Kazani S(2013)Use of NSAIDs in treating patients with arthritis Arthritis Res Ther 15 356-2238

[10] Planaguma A(2018)Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: a structure-based approach Eur J Pharm Sci 121 999-998

[1] Wang B(2021)Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets Signal Transduct Target Ther 6 94-1521

[2] Wu L(2019)Brief story on prostaglandins, inhibitors of their synthesis, hematopoiesis and acute radiation syndrome Molecules 24 4019-553

[3] Chen J(2014)Inflammation, cancer and oxidative lipoxygenase activity are intimately linked Cancers (Basel) 6 1500-460

[4] Hofer M(2013)Exhaled breath condensate eicosanoid levels associate with asthma and its severity J Allergy Clin Immunol 132 547-110s

[5] Hoferová Z(2014)Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis Arthritis Res Ther 16 496-10

[6] Falk M(2014)5-lipoxygenase inhibitors attenuate TNF-α-Induced inflammation in human synovial fibroblasts PLoS ONE 9 452-381

[7] Wisastra R(2017)Critical role of LTB 4/BLT1 in IL-23–induced synovial inflammation and osteoclastogenesis via NF-κB J Immunol 198 81s-1006

[8] Dekker FJ(2008)Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond J Pharm Pharm Sci 11 1-324

[9] Kazani S(2013)Use of NSAIDs in treating patients with arthritis Arthritis Res Ther 15 356-2238

[10] Planaguma A(2018)Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: a structure-based approach Eur J Pharm Sci 121 999-998