Dabigatran EtexilateA Review of its Use in the Prevention of Stroke and Systemic Embolism in Patients with Atrial Fibrillation

被引：0
作者：
Karly P. Garnock-Jones
机构：
[1] Adis,
[2] a Wolters Kluwer Business,undefined
来源：
American Journal of Cardiovascular Drugs | 2011年 / 11卷
关键词：
Atrial Fibrillation; Warfarin; International Normalize Ratio; Dabigatran; Major Bleeding;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The need for safe, effective, and easily administered and monitored antithrombotic treatments that do not have the issues common to warfarin treatment has led to the development of new anticoagulant drugs. Dabigatran etexilate (Pradaxa®, Pradax™) is a prodrug of the direct thrombin inhibitor dabigatran, a direct, reversible, potent inhibitor of thrombin. Dabigatran does not interact with food, and is associated with very few known drug interactions.
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页码：57 / 72
页数：15
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  • [1] Lafuente-Lafuente C.(2010)Management of atrial fibrillation BMJ 340 40-5
  • [2] Mahe I.(2008)Will warfarin soon be passe? New approaches to stroke prevention in atrial fibrillation J Cardiovasc Pharmacol 52 18-27
  • [3] Extramiana F.(2009)The current role of anticoagulants in cardiovascular medicine J Cardiovasc Med 10 595-604
  • [4] Hammwöhner M.(2009)The RE-LY study: Randomized Evaluation of Long-term anticoagulant therapY. Dabigatran vs. warfarin Eur Heart J 30 2554-5
  • [5] Goette A.(2010)Dabigatran challenges warfarin’s superiority for stroke prevention in atrial fibrillation Stroke 41 1307-9
  • [6] De Caterina R.(2007)Challenges of establishing new antithrombotic therapies in atrial fibrillation Circulation 116 449-55
  • [7] Camm A.J.(2008)Dabigatran etexilate Drugs 68 1699-709
  • [8] Schwartz N.E.(2007)In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate Thromb Haemost 98 155-62
  • [9] Albers G.W.(2007)Effects of dabigatran, a direct thrombin inhibitor, as compared to the direct factor Xa inhibitors, rivaroxaban and apixaban, on tissue factor-induced human platelet aggregation in platelet rich plasma [abstract no. 1884] Blood 110 558a-8
  • [10] Connolly S.J.(2007)Dabigatran inhibits both clot-bound and fluid phase thrombin in vitro: effects compared to heparin and hirudin [abstract no. 3998] Blood 110 68B-68
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