Effect of Octreotide on Human Sphincter of Oddi Motility Following Liver Transplantation

The effect of octreotide on sphincter of Oddimotility was investigated in six liver transplantpatients, employing percutaneous (through the T-tubetract) manometry. Continuous and simultaneous sphincter of Oddi and duodenal motor activities wererecorded before and for 60 min after the administrationof octreotide (100 μg subcutaneously) and after theinjection of cholecystokinin (0.02 μg/kgintravenously). With octreotide, contraction frequency andbasal pressure significantly increased (P < 0.05).This effect lasted more than 60 min, long afteroctreotide-induced duodenal migrating motor complexphase III activity had ceased. Sphincter of Oddicontraction amplitude and duration were unaffected byoctreotide. Subsequent cholecystokinin administrationtransiently reduced sphincter of Oddi basal pressure and contraction frequency. We conclude thatoctreotide significantly increases sphincter of Oddibasal pressure and contraction frequency. This effect isdistinct from octreotide induction of migrating motor complex phase III activity, persists for aprolonged period, and is inhibited bycholecystokinin.