Cordyceps bassiana inhibits smooth muscle cell proliferation via the ERK1/2 MAPK signaling pathway

被引：0
作者：
Enze Jin
Seongho Han
Mina Son
Sung-Whan Kim
机构：
[1] The Fourth Affiliated Hospital of Harbin Medical University,Department of Cardiology
[2] Dong-A University,Department of Family Medicine, College of Medicine
[3] Catholic Kwandong University,Department of Medicine, College of Medicine
[4] International St. Mary’s Hospital,undefined
来源：
Cellular & Molecular Biology Letters | 2016年 / 21卷
关键词：
Cordyceps; ERK pathway; Inhibitory; MAPK; Mechanism; Natural product; Neointimal formation; Proliferation; Smooth muscle cells; Vascular;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cordyceps belongs to a genus of acormycete fungi and is known to exhibit various pharmacological effects. The aim of this study was to investigate the effect of Cordyceps species on the proliferation of vascular smooth muscle cells (VSMC) and their underlying molecular mechanism. A cell proliferation assay showed that Cordyceps bassiana ethanol extract (CBEE) significantly inhibited VSMC proliferation. In addition, neointimal formation was significantly reduced by treatment with CBEE in the carotid artery of balloon-injured rats. We also investigated the effects of CBEE on the extracellular signal-regulated kinase (ERK) signal pathway. Western blot analysis revealed increased ERK 1/2 phosphorylation in VSMCs treated with CBEE. Pretreatment with U0126 completely abrogated CBEE-induced ERK 1/2 phosphorylation. In conclusion, CBEE exhibited anti-proliferative properties that affected VSMCs through the ERK1/2 MAPK signaling pathway. Our data may elucidate the inhibitory mechanism of this natural product.
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