High expression of ABCF1 is an independent predictor of poor prognosis in bladder cancer

被引：0
作者：
JiaWen Fan
Yi Ding
HaoXuan Huang
ShiDa Xiong
Liang He
Ju Guo
机构：
[1] The First Affiliated Hospital of Nanchang University,Department of Urology
[2] The Second Affiliated Hospital of Jiujiang University,undefined
来源：
BMC Urology | / 23卷
关键词：
Bladder cancer; ABCF1; GSEA; Prognosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
ABCF1, a member of the ATP-binding cassette (ABC) transporter family, is involved in the malignant progression of tumors. However, the role of ABCF1 in bladder cancer is poorly understood. In our study, we explored the differential expression of ABCF1 in bladder cancer and normal bladder tissues based on bioinformatic analysis and immunohistochemical results. GSEA was performed to ascertain the potential related signaling pathways of ABCF1. The relationship between ABCF1 expression and bladder cancer progression was analyzed using the GSE13507 dataset. In addition, the differential expression of ABCF1 in the cell lines was verified by quantitative real-time polymerase chain reaction (qRT‒PCR) and Western blotting. ABCF1 was upregulated in bladder cancer, and the high expression of ABCF1 was closely related to sex (P = 0.00056), grade (P = 0.00049), T stage (P = 0.00007), and N stage (P = 0.0076). High expression of ABCF1 was correlated with poor overall survival in bladder cancer patients (P < 0.001). In addition, univariate and multivariate Cox regression analyses showed that high ABCF1 expression was an independent factor for poor prognosis in bladder cancer patients. Therefore, ABCF1 expression is closely related to the progression of bladder cancer and can be used as a potential indicator of poor prognosis and a therapeutic target for bladder cancer.
引用
收藏
相关论文
共 244 条
  • [11] Znaor A(2015)Inhibition of ABCB1 overcomes cancer stem cell-like properties and acquired resistance to MET inhibitors in non-small cell lung cancer Mol Cancer Ther 14 2433-2440
  • [12] Jemal A(1998)ABC50, a novel human ATP-Binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes Genomics 53 137-145
  • [13] Bray F(2000)ABC50 interacts with eukaryotic initiation factor 2 and associates with the ribosome in an ATP-dependent manner J Biol Chem 275 34131-34139
  • [14] Cao R(2015)ABC50 mutants modify translation start codon selection Biochem J 467 217-229
  • [15] Yuan L(2009)ABC50 promotes translation initiation in mammalian cells J Biol Chem 284 24061-24073
  • [16] Ma B(2013)Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach Nat Immunol 14 179-185
  • [17] Wang G(2017)The role of the innate immune response regulatory gene ABCF1 in mammalian embryogenesis and development Plos One 12 e0175918-U39
  • [18] Qiu W(2012)Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor Cell Death Dis 3 23-13960
  • [19] Tian Y(2010)Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors Trans Oncol 24 13949-30
  • [20] Tran L(2020)IGF2BP3 facilitates cell proliferation and tumorigenesis via modulation of JAK/STAT signalling pathway in human bladder cancer J Cell Mol Med 28 27-1951
12345678910