Optimization of enantioselective synthesis of methyl (R)-2-chloromandelate by whole cells of Saccharomyces cerevisiae

被引：0
|
作者：
Min Jeong
Yoon Mi Lee
Soon Ho Hong
Sung Young Park
Ik-keun Yoo
Mee Jung Han
机构：
[1] University of Ulsan,School of Chemical Engineering and Bioengineering
[2] Ulsan Fine Chemical Industry Center,Department of Chemical and Biological Engineering
[3] Chungju National University,School of Chemical and Biomolecular Engineering
[4] Dongyang University,undefined
来源：
Biotechnology Letters | 2010年 / 32卷
关键词：
Asymmetric reduction; Biotransformation; Methyl (; )-2-chloromandelate;
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学科分类号：
摘要：
Methyl (R)-2-chloromandelate, a key intermediate in the synthesis of clopidogrel, was obtained by the reduction of methyl-2-chlorobenzoylformate using whole cells of Saccharomyces cerevisiae. A 100% conversion and 96.1% of enantiomeric excess (ee) value was obtained when 17 methyl-2-chlorobenzoylformate/l was reacted with 8 g S. cerevisiae/l and 83 g glucose/l at pH 7.
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页码：1529 / 1531
页数：2
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