Optimization of enantioselective synthesis of methyl (R)-2-chloromandelate by whole cells of Saccharomyces cerevisiae

被引：0

作者：

Min Jeong

Yoon Mi Lee

Soon Ho Hong

Sung Young Park

Ik-keun Yoo

Mee Jung Han

机构：

[1] University of Ulsan,School of Chemical Engineering and Bioengineering

[2] Ulsan Fine Chemical Industry Center,Department of Chemical and Biological Engineering

[3] Chungju National University,School of Chemical and Biomolecular Engineering

[4] Dongyang University,undefined

来源：

Biotechnology Letters | 2010年 / 32卷

关键词：

Asymmetric reduction; Biotransformation; Methyl (; )-2-chloromandelate;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Methyl (R)-2-chloromandelate, a key intermediate in the synthesis of clopidogrel, was obtained by the reduction of methyl-2-chlorobenzoylformate using whole cells of Saccharomyces cerevisiae. A 100% conversion and 96.1% of enantiomeric excess (ee) value was obtained when 17 methyl-2-chlorobenzoylformate/l was reacted with 8 g S. cerevisiae/l and 83 g glucose/l at pH 7.

引用

页码：1529 / 1531

页数：2

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