Effects of adenosine triphosphate concentration on motor force regulation during skeletal muscle contraction

被引：0
|
作者：
J. Wei
C. Dong
B. Chen
机构：
[1] Zhejiang University,Department of Engineering Mechanics
来源：
Acta Mechanica Sinica | 2017年 / 33卷
关键词：
Motor force regulation; ATP; Muscle contraction; Myosin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We employ a mechanical model of sarcomere to quantitatively investigate how adenosine triphosphate (ATP) concentration affects motor force regulation during skeletal muscle contraction. Our simulation indicates that there can be negative cross-bridges resisting contraction within the sarcomere and higher ATP concentration would decrease the resistance force from negative cross-bridges by promoting their timely detachment. It is revealed that the motor force is well regulated only when ATP concentration is above a certain level. These predictions may provide insights into the role of ATP in regulating coordination among multiple motors.
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页码：243 / 249
页数：6
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