Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells

[1] Kaiser N(1993)Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells Diabetes 42 80-89

[2] Sasson S(2001)Biochemistry and molecular cell biology of diabetic complications Nature 414 813-820

[3] Feener EP(1997)High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria FEBS Lett 416 15-18

[4] Brownlee M(2006)Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol Biochim Biophys Acta 1757 535-452

[5] Korshunov SS(2010)Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase Free Radic Res 44 313-321

[6] Skulachev VP(2000)Normalising mitochondrial superoxide production blocks three pathways of hyperglycaemic damage Nature 404 787-790

[7] Starkov AA(2008)Gamma-H2AX—a novel biomarker for DNA double-strand breaks In Vivo 22 305-309

[8] Boveris A(2010)DNA-PKCs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression BMC Mol Biol 11 18-895

[9] Valdez LB(2000)A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage Curr Biol 10 886-5694

[10] Zaobornyj T(2008)Gamma-H2AX in recognition and signalling of DNA double-strand breaks in the context of chromatin Nucleic Acids Res 36 5678-929

[1] Kaiser N(1993)Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells Diabetes 42 80-89

[2] Sasson S(2001)Biochemistry and molecular cell biology of diabetic complications Nature 414 813-820

[3] Feener EP(1997)High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria FEBS Lett 416 15-18

[4] Brownlee M(2006)Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol Biochim Biophys Acta 1757 535-452

[5] Korshunov SS(2010)Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase Free Radic Res 44 313-321

[6] Skulachev VP(2000)Normalising mitochondrial superoxide production blocks three pathways of hyperglycaemic damage Nature 404 787-790

[7] Starkov AA(2008)Gamma-H2AX—a novel biomarker for DNA double-strand breaks In Vivo 22 305-309

[8] Boveris A(2010)DNA-PKCs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression BMC Mol Biol 11 18-895

[9] Valdez LB(2000)A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage Curr Biol 10 886-5694

[10] Zaobornyj T(2008)Gamma-H2AX in recognition and signalling of DNA double-strand breaks in the context of chromatin Nucleic Acids Res 36 5678-929