Hematopoietic stem cell transplantation for adults with relapsed acute promyelocytic leukemia in second complete remission

被引：0

作者：

Jaime Sanz

Myriam Labopin

Miguel A. Sanz

Mahmoud Aljurf

Aida Botelho Sousa

Charles Craddock

Tsila Zuckerman

Hélène Labussière-Wallet

Antonio Campos

Giovanni Grillo

Zubeyde Nur Ozkurt

J. J. Cornelissen

Péter Reményi

Massimo Martino

Rocio Parody Porras

Arnon Nagler

Norbert-Claude Gorin

Mohamad Mohty

机构：

[1] Hospital Universitari i Politècnic La Fe,Hematology Department

[2] CIBERONC,EBMT Paris Office

[3] Instituto Carlos III,Hôpital Saint Antoine, Sorbonne University

[4] Hospital Saint Antoine,Oncology Center

[5] Department of Hematology,Hospital dos Capuchos

[6] King Faisal Specialist Hospital and Research Centre,University Hospital Birmingham NHSTrust, Queen Elizabeth Medical Centre, Edgbaston

[7] Servico de Hematologia,Rambam Health Care Campus, Department of Hematology & BMT and Faculty of Medicine

[8] Department of Haematology,Hôpital Lyon Sud

[9] Technion,Inst. Português de Oncologia do Porto

[10] Hospices Civils de Lyon Pierre Benite,ASST Grande Ospedale Metropolitano Niguarda

[11] BMT Unit,Erasmus MC Cancer Institute,University Medical Center Rotterdam

[12] Hematology Department,Dél

[13] Gazi University Faculty of Medicine,pesti Centrumkórház

[14] Department of Hematology,Stem Cell Transplantation Unit (CTMO), Department of Hemato

[15] Department of Haematology and Stem Cell Transplant,Oncology and Radiotherapy

[16] Grande Ospedale Metropolitano “Bianchi-Melacrino-Morelli”,Division of Hematology and Bone Marrow Transplantation

[17] ICO–Hospital Duran i Reynals,ALWP of the EBMT Office

[18] L’Hospitalet de Llobregat,undefined

[19] The Chaim Sheba Medical Center,undefined

[20] Saint Antoine Hospital,undefined

来源：

Bone Marrow Transplantation | 2021年 / 56卷

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摘要：

We retrospectively compared outcomes of a large series of adult patients with APL in CR2 receiving alloHSCT (n = 228) or autoHSCT (n = 341) reported to the European Society for Blood and Marrow Transplantation from January 2004 to December 2018. The 2-year cumulative incidence of non-relapse mortality was significantly higher for alloHSCT 17.3% (95% CI 12.5–22.8) compared with autoHSCT 2.7% (95% CI 1.2–5) (p = 0.001), while differences in relapse rate were not significant (28% versus 22.9%; p = 0.28). Leukemia-free survival (LFS) and overall survival (OS) favored autoHSCT with 74.5% (95% CI 69–79.2) and 82.4% (95% CI 77.3–86.5) compared with alloHSCT with 54.7% (95% CI 47.5–61.3) (p = 0.001) and 64.3% (95% CI 57.2–70.6), respectively (p = 0.001 and p = 0.001). Multivariable analysis showed significantly worse LFS after alloHSCT (HR 0.49; 95% CI 0.37–0.67; p < 0.0001), older age (p = 0.001), and shorter time from diagnosis to transplant (p = 0.00015). Similar results were obtained for OS. The study shows that autoHSCT resulted in better survival outcomes (LFS and OS) for APL in CR2. These results were mainly due to reduced NRM in the autoHSCT as compared to alloHSCT.

引用

页码：1272 / 1280

页数：8

共 84 条

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