Synthesis and preliminary evaluation of 68Ga-NOTA-IF7 as a tumor imaging agent

被引：0

作者：

Xiaobo Gu

Gangming Cai

Rongjun Zhang

Mengjun Jiang

Yaoyuan Zhou

Donghui Pan

Yuping Xu

Hongbo Huang

机构：

[1] Jiangsu Institute of Nuclear Medicine,Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine

[2] The First Wuxi Affiliated Hospital of Nanjing Medical University,Department of Clinical Laboratory Science

来源：

Journal of Radioanalytical and Nuclear Chemistry | 2015年 / 303卷

关键词：

Annexin A1; NOTA; Ga-NOTA-IF7; MicroPET imaging; U118 Tumor; Tumor vasculature imaging;

D O I：

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学科分类号：

摘要：

With the aim of developing a new tumor imaging agent, the IFLLWQR (Ile-Phe-Leu–Leu-Trp-Glu-Arg, IF7) was conjugated with 1, 4, 7-triazacyclononane-N, N’, N’’-triacetic acid (NOTA) and labeled with 68Ga. In the optimal conditions, the whole radio-synthesis was accomplished within 20 min. The decay-corrected radiochemical yield was more than 92 %. The radiochemical purity of 68Ga-NOTA-IF7 was more than 95 %. MicroPET studies showed a high tumor uptake at 15 min post-injection with 7.52 ± 0.16 %ID/g. The ratios of tumor to muscle uptake were 20.61 ± 0.31, 13.14 ± 0.21, 2.39 ± 0.12 at 15 min, 30 min and 60 min post-injection, respectively. 68Ga-NOTA-IF7 is a promising radiopharmaceutical for tumor imaging.

引用

页码：777 / 782

页数：5