Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

被引：0
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作者：
Matan Sorek
Walaa Oweis
Malka Nissim-Rafinia
Moria Maman
Shahar Simon
Cynthia C. Hession
Xian Adiconis
Sean K. Simmons
Neville E. Sanjana
Xi Shi
Congyi Lu
Jen Q. Pan
Xiaohong Xu
Mahmoud A. Pouladi
Lisa M. Ellerby
Feng Zhang
Joshua Z. Levin
Eran Meshorer
机构：
[1] The Hebrew University of Jerusalem,Department of Genetics, The Alexander Silberman Institute of Life Sciences, Edmond J. Safra Campus
[2] The Hebrew University of Jerusalem,The Edmond and Lily Center for Brain Sciences, Edmond J. Safra Campus
[3] Broad Institute of MIT and Harvard,Stanley Center for Psychiatric Research
[4] Broad Institute of MIT and Harvard,Klarman Cell Observatory
[5] Broad Institute of MIT and Harvard,McGovern Institute for Brain Research
[6] Massachusetts Institute of Technology,New York Genome Center and Department of Biology
[7] New York University,Department of Neurology and Stroke Center, The First Affiliated Hospital
[8] Jinan University,Translational Laboratory in Genetic Medicine (TLGM), Agency for Science
[9] Technology and Research (A*STAR),Department of Physiology
[10] National University of Singapore,British Columbia Children’s Hospital Research Institute, Department of Medical Genetics
[11] University of British Columbia,Department of Biological Engineering
[12] Buck Institute for Research on Aging,Department of Brain and Cognitive Sciences
[13] Massachusetts Institute of Technology,undefined
[14] Massachusetts Institute of Technology,undefined
来源：
Genome Biology | / 22卷
关键词：
Transcriptional heterogeneity; Single cell; scRNA-seq; Neurological diseases; Neurodegenerative diseases; Huntington’s disease; Pluripotent stem cells; Stem cell model; Smart-seq2;
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