Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

被引：0
|
作者：
Matan Sorek
Walaa Oweis
Malka Nissim-Rafinia
Moria Maman
Shahar Simon
Cynthia C. Hession
Xian Adiconis
Sean K. Simmons
Neville E. Sanjana
Xi Shi
Congyi Lu
Jen Q. Pan
Xiaohong Xu
Mahmoud A. Pouladi
Lisa M. Ellerby
Feng Zhang
Joshua Z. Levin
Eran Meshorer
机构：
[1] The Hebrew University of Jerusalem,Department of Genetics, The Alexander Silberman Institute of Life Sciences, Edmond J. Safra Campus
[2] The Hebrew University of Jerusalem,The Edmond and Lily Center for Brain Sciences, Edmond J. Safra Campus
[3] Broad Institute of MIT and Harvard,Stanley Center for Psychiatric Research
[4] Broad Institute of MIT and Harvard,Klarman Cell Observatory
[5] Broad Institute of MIT and Harvard,McGovern Institute for Brain Research
[6] Massachusetts Institute of Technology,New York Genome Center and Department of Biology
[7] New York University,Department of Neurology and Stroke Center, The First Affiliated Hospital
[8] Jinan University,Translational Laboratory in Genetic Medicine (TLGM), Agency for Science
[9] Technology and Research (A*STAR),Department of Physiology
[10] National University of Singapore,British Columbia Children’s Hospital Research Institute, Department of Medical Genetics
[11] University of British Columbia,Department of Biological Engineering
[12] Buck Institute for Research on Aging,Department of Brain and Cognitive Sciences
[13] Massachusetts Institute of Technology,undefined
[14] Massachusetts Institute of Technology,undefined
来源：
Genome Biology | / 22卷
关键词：
Transcriptional heterogeneity; Single cell; scRNA-seq; Neurological diseases; Neurodegenerative diseases; Huntington’s disease; Pluripotent stem cells; Stem cell model; Smart-seq2;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Qualitative transcriptional signatures for evaluating the maturity degree of pluripotent stem cell-derived cardiomyocytes
    Rou Chen
    Jun He
    Yumei Wang
    You Guo
    Juan Zhang
    Luying Peng
    Duo Wang
    Qin Lin
    Jie Zhang
    Zheng Guo
    Li Li
    Stem Cell Research & Therapy, 10
  • [22] Pluripotent stem cell-derived cardiac microtissues
    Laffman-Johnson, Elise
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2014, 95 (03) : 237 - 237
  • [23] Application of human pluripotent stem cells and pluripotent stem cell-derived cellular models for assessing drug toxicity
    Apati, Agota
    Varga, Nora
    Berecz, Tunde
    Erdei, Zsuzsa
    Homolya, Laszlo
    Sarkadi, Balazs
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2019, 15 (01) : 61 - 75
  • [24] Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity
    Rufaihah, Abdul Jalil
    Huang, Ngan F.
    Kim, Jeanna
    Herold, Joerg
    Volz, Katharina S.
    Park, Tea Soon
    Lee, Jerry C.
    Zambidis, Elias T.
    Reijo-Pera, Renee
    Cooke, John P.
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2013, 5 (01): : 21 - U122
  • [25] Prospects for Pluripotent Stem Cell-Derived Cardiomyocytes in Cardiac Cell Therapy and as Disease Models
    Freund, Christian
    Mummery, Christine L.
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 107 (04) : 592 - 599
  • [26] Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Acquire Rejuvenation and Reduced Heterogeneity
    Wruck, Wasco
    Graffmann, Nina
    Spitzhorn, Lucas-Sebastian
    Adjaye, James
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [27] Biotechnological advances and applications of human pluripotent stem cell-derived heart models
    Muniyandi, Priyadharshni
    O'Hern, Colin
    Popa, Mirel Adrian
    Aguirre, Aitor
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023, 11
  • [28] Induced pluripotent stem cell-derived cardiomyocytes as models for genetic cardiovascular disorders
    Josowitz, Rebecca
    Carvajal-Vergara, Xonia
    Lemischka, Ihor R.
    Gelb, Bruce D.
    CURRENT OPINION IN CARDIOLOGY, 2011, 26 (03) : 223 - 229
  • [29] Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations
    N Farra
    W-B Zhang
    P Pasceri
    J H Eubanks
    M W Salter
    J Ellis
    Molecular Psychiatry, 2012, 17 : 1261 - 1271
  • [30] Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins
    Kim, Hyosung
    Xu, Ranjie
    Padmashri, Ragunathan
    Dunaevsky, Anna
    Liu, Ying
    Dreyfus, Cheryl F.
    Jiang, Peng
    STEM CELL REPORTS, 2019, 12 (05): : 890 - 905
12345