Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity

[21] Yin R(2006)Design, synthesis, and biological evaluation of substituted 3-alkylthio-4,5-diaryl-4H-1,2,4-triazoles as selective COX-2 inhibitors Bioorg Med Chem 14 2507-2517

[22] Li M(2007)1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities Bioorg Med Chem 15 5738-5751

[23] Zhang Z(2007)Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents Eur J Med Chem 42 893-901

[24] Jiang F(2008)comparative structure-activity relationship studies of 1-(5-methylsulfonylpyrid-2-Yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition Bioorg Med Chem Lett 18 1042-1045

[25] Xu L(2019)New ibuprofen derivatives as H Future Med Chem 11 3029-3045

[26] Chen EP(2016)S and NO donors as safer anti-inflammatory agents Eur J Med Chem 121 58-70

[27] Smyth EM(2020)Synthesis and antiproliferative evaluation of novel 2-(4H–1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells J Res Pharm 24 436-451

[28] Ruan D(2021)Synthesis, in silico studies and cytotoxicity evaluation of novel 1,3,4-oxadiazole derivatives designed as potential MPGES-1 ınhibitors Mol Divers 25 403-420

[29] So SP(2020)Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through Inhibition of STAT3: synthesis and in silico mechanistic studies Arch Pharm (Weinheim) 353 e2000170-3309

[30] Nakanishi M(2013)Novel 1,2,4-triazole derivatives: design, synthesis, anticancer evaluation, molecular docking, and pharmacokinetic profiling studies J Med Chem 56 3296-537

[21] Yin R(2006)Design, synthesis, and biological evaluation of substituted 3-alkylthio-4,5-diaryl-4H-1,2,4-triazoles as selective COX-2 inhibitors Bioorg Med Chem 14 2507-2517

[22] Li M(2007)1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities Bioorg Med Chem 15 5738-5751

[23] Zhang Z(2007)Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents Eur J Med Chem 42 893-901

[24] Jiang F(2008)comparative structure-activity relationship studies of 1-(5-methylsulfonylpyrid-2-Yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition Bioorg Med Chem Lett 18 1042-1045

[25] Xu L(2019)New ibuprofen derivatives as H Future Med Chem 11 3029-3045

[26] Chen EP(2016)S and NO donors as safer anti-inflammatory agents Eur J Med Chem 121 58-70

[27] Smyth EM(2020)Synthesis and antiproliferative evaluation of novel 2-(4H–1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells J Res Pharm 24 436-451

[28] Ruan D(2021)Synthesis, in silico studies and cytotoxicity evaluation of novel 1,3,4-oxadiazole derivatives designed as potential MPGES-1 ınhibitors Mol Divers 25 403-420

[29] So SP(2020)Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through Inhibition of STAT3: synthesis and in silico mechanistic studies Arch Pharm (Weinheim) 353 e2000170-3309

[30] Nakanishi M(2013)Novel 1,2,4-triazole derivatives: design, synthesis, anticancer evaluation, molecular docking, and pharmacokinetic profiling studies J Med Chem 56 3296-537