Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity

被引：0

作者：

Bahadır Bülbül

Kai Ding

Chang-Guo Zhan

Gamze Çiftçi

Kemal Yelekçi

Merve Gürboğa

Özlem Bingöl Özakpınar

Esra Aydemir

Deniz Baybağ

Fikrettin Şahin

Necla Kulabaş

Sinem Helvacıoğlu

Mohammad Charehsaz

Esra Tatar

Süheyla Özbey

İlkay Küçükgüzel

机构：

[1] Düzce University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy

[2] Marmara University,Department of Pharmaceutical Chemistry, Institute of Health Sciences

[3] University of Kentucky,Department of Pharmaceutical Sciences, College of Pharmacy

[4] University of Kentucky,Center for Pharmaceutical Research and Innovation, College of Pharmacy

[5] Kadir Has University,Department of Bioinformatics and Genetics, Faculty of Engineering and Natural Sciences

[6] Marmara University,Department of Biochemistry, Faculty of Pharmacy

[7] Yeditepe University,Department of Genetics and Bioengineering, Faculty of Engineering

[8] Biruni University,Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences

[9] Marmara University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy

[10] Yeditepe University,Department of Toxicology, Faculty of Pharmacy

[11] Hacettepe University,Department of Physics Engineering, Faculty of Engineering

来源：

Molecular Diversity | 2023年 / 27卷

关键词：

1,2,4-Triazole; Atropisomer; Diastereotope; X-ray diffraction; Cancer; Angiogenesis; mPGES-1; Cytotoxicity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

页码：2185 / 2215

页数：30

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[10] Reber HA(2009)Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells Proc Natl Acad Sci 106 18757-18762