Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia

被引：11

作者：

Lee, Chel Hee ^{[1
]}

Banoei, Mohammad M. ^{[1
]}

Ansari, Mariam ^{[1
]}

Cheng, Matthew P. ^{[2
,3
]}

Lamontagne, Francois ^{[4
]}

Griesdale, Donald ^{[5
,6
]}

Lasry, David E. ^{[2
,3
]}

Demir, Koray ^{[2
,3
]}

Dhingra, Vinay ^{[5
,6
]}

Tran, Karen C. ^{[6
,7
]}

Lee, Terry ^{[8
,9
]}

Burns, Kevin ^{[10
,11
]}

Sweet, David ^{[6
,12
]}

Marshall, John ^{[13
,14
]}

Slutsky, Arthur ^{[15
,16
]}

Murthy, Srinivas ^{[17
]}

Singer, Joel ^{[8
,9
]}

Patrick, David M. ^{[18
,19
]}

Lee, Todd C. ^{[2
,3
]}

Boyd, John H. ^{[20
,21
]}

Walley, Keith R. ^{[20
,21
]}

Fowler, Robert ^{[22
]}

Haljan, Greg ^{[26
]}

Vinh, Donald C. ^{[2
,3
]}

Mcgeer, Alison ^{[27
,28
]}

Maslove, David ^{[29
,30
]}

Mann, Puneet ^{[31
]}

Donohoe, Kathryn ^{[31
]}

Hernandez, Geraldine ^{[31
]}

Rocheleau, Genevieve ^{[31
]}

Trahtemberg, Uriel ^{[32
,33
,34
]}

Kumar, Anand ^{[35
,36
]}

Lou, Ma ^{[35
,36
]}

dos Santos, Claudia ^{[37
,38
]}

Baker, Andrew ^{[39
,40
]}

Russell, James A. ^{[20
,21
]}

Winston, Brent W. ^{[23
,24
,25
]}

机构：

[1] Univ Calgary, Dept Crit Care Med, Calgary, AB, Canada

[2] McGill Univ, Div Infect Dis, McGills Interdisciplinary Initiat Infect & Immun, Hlth Ctr, Montreal, PQ, Canada

[3] McGill Univ, Div Med Microbiol, McGills Interdisciplinary Initiat Infect & Immun, Hlth Ctr, Montreal, PQ, Canada

[4] Univ Sherbrooke, Sherbrooke, PQ, Canada

[5] Vancouver Gen Hosp, Crit Care Med, 2775 Laurel St, Vancouver, BC V5Z 1M9, Canada

[6] Univ British Columbia, 2775 Laurel St, Vancouver, BC V5Z 1M9, Canada

[7] Vancouver Gen Hosp, Div Gen Internal Med, 2775 Laurel St, Vancouver, BC V5Z 1M9, Canada

[8] St Pauls Hosp, Ctr Hlth Evaluat & Outcome Sci CHEOS, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada

[9] Univ British Columbia, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada

[10] Ottawa Hosp, Dept Med, Div Nephrol, Res Inst, 1967 Riverside Dr,Rm 535, Ottawa, ON K1H 7W9, Canada

[11] Univ Ottawa, 1967 Riverside Dr,Rm 535, Ottawa, ON K1H 7W9, Canada

[12] Vancouver Gen Hosp, Crit Care Med & Emergency Med, 2775 Laurel St, Vancouver, BC V5Z 1M9, Canada

[13] St Michaels Hosp, Dept Surg, 30 Bond St, Toronto, ON M5B 1W8, Canada

[14] Univ Toronto, 30 Bond St, Toronto, ON M5B 1W8, Canada

[15] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada

[16] Univ Toronto, Interdept Div Crit Care Med, Toronto, ON, Canada

[17] Univ British Columbia, British Columbia Childrens Hosp, 4500 Oak St, Vancouver, BC V6H 3N1, Canada

[18] Univ British Columbia, British Columbia Ctr Dis Control BCCDC, 655 West 12th Ave, Vancouver, BC V5Z 4R4, Canada

[19] Univ British Columbia, Sch Populat & Publ Hlth, 655 West 12th Ave, Vancouver, BC V5Z 4R4, Canada

[20] Univ British Columbia, St Pauls Hosp, Ctr Heart Lung Innovat, Vancouver, BC, Canada

[21] Univ British Columbia, St Pauls Hosp, Div Crit Care Med, Vancouver, BC, Canada

[22] Sunnybrook Hlth Sci Ctr, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada

[23] Univ Calgary, Hlth Res Innovat Ctr HRIC, Dept Crit Care Med, Room 4C64,3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada

[24] Univ Calgary, Hlth Res Innovat Ctr HRIC, Dept Med & Biochem, Room 4C64,3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada

[25] Univ Calgary, Hlth Res Innovat Ctr HRIC, Dept Mol Biol, Room 4C64,3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada

[26] Surrey Mem Hosp, Dept Med & Crit Care Med, 13750 96th Ave, Surrey, BC V3V 1Z2, Canada

[27] Mt Sinai Hosp, 600 Univ Ave, Toronto, ON M5G 1X5, Canada

[28] Univ Toronto, 600 Univ Ave, Toronto, ON M5G 1X5, Canada

[29] Kingston Gen Hosp, Dept Crit Care, 76 Stuart St, Kingston, ON K7L 2V7, Canada

[30] Queens Univ, 76 Stuart St, Kingston, ON K7L 2V7, Canada

[31] Black Tusk, Vancouver, BC, Canada

[32] Galilee Med Ctr, Dept Crit Care, Nahariyya, Israel

[33] Bar Ilan Univ, Ramat Gan, Israel

[34] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada

[35] Univ Manitoba, Dept Med, Winnipeg, MB, Canada

[36] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

[37] Univ Toronto, Dept Med, Toronto, ON, Canada

[38] Univ Toronto, Interdept Div Crit Care, Toronto, ON, Canada

[39] Univ Toronto, St Michaels Hosp, Dept Crit Care, Toronto, ON, Canada

[40] Univ Toronto, St Michaels Hosp, Dept Anesthesia, Toronto, ON, Canada

来源：

CRITICAL CARE | 2024年 / 28卷 / 01期

关键词：

Acute respiratory distress syndrome; SARS-CoV-2; Pneumonia; Metabolomics; RESPIRATORY-DISTRESS-SYNDROME; SUBPHENOTYPES;

D O I：

10.1186/s13054-024-04843-0

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

RationaleAcute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome commonly associated with infections such as COVID-19, influenza, and bacterial pneumonia. Ongoing research aims to improve our understanding of ARDS, including its molecular mechanisms, individualized treatment options, and potential interventions to reduce inflammation and promote lung repair.ObjectiveTo map and compare metabolic phenotypes of different infectious causes of ARDS to better understand the metabolic pathways involved in the underlying pathogenesis.MethodsWe analyzed metabolic phenotypes of 3 ARDS cohorts caused by COVID-19, H1N1 influenza, and bacterial pneumonia compared to non-ARDS COVID-19-infected patients and ICU-ventilated controls. Targeted metabolomics was performed on plasma samples from a total of 150 patients using quantitative LC-MS/MS and DI-MS/MS analytical platforms.ResultsDistinct metabolic phenotypes were detected between different infectious causes of ARDS. There were metabolomics differences between ARDSs associated with COVID-19 and H1N1, which include metabolic pathways involving taurine and hypotaurine, pyruvate, TCA cycle metabolites, lysine, and glycerophospholipids. ARDSs associated with bacterial pneumonia and COVID-19 differed in the metabolism of D-glutamine and D-glutamate, arginine, proline, histidine, and pyruvate. The metabolic profile of COVID-19 ARDS (C19/A) patients admitted to the ICU differed from COVID-19 pneumonia (C19/P) patients who were not admitted to the ICU in metabolisms of phenylalanine, tryptophan, lysine, and tyrosine. Metabolomics analysis revealed significant differences between C19/A, H1N1/A, and PNA/A vs ICU-ventilated controls, reflecting potentially different disease mechanisms.ConclusionDifferent metabolic phenotypes characterize ARDS associated with different viral and bacterial infections.

引用

页数：16

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