Development and validation of computational models of cellular interaction

被引：0

作者：

Smallwood R.H. ^{[1
]}

Holcombe W.M.L. ^{[1
]}

Walker D.C. ^{[1
]}

机构：

[1] Department of Computer Science, University of Sheffield, Sheffield S1 4DP

来源：

Journal of Molecular Histology | 2004年 / 35卷 / 7期

关键词：

Biological System; Computational Model; System Biology; Biological Model; Cellular Interaction;

D O I：

10.1007/s10735-004-2660-1

中图分类号：

学科分类号：

摘要：

In this paper we take the view that computational models of biological systems should satisfy two conditions - they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be available. A modelling paradigm for developing a predictive computational model of cellular interaction is described, and methods of providing robust validation against biological models are explored, followed by a consideration of software issues. © 2004 Kluwer Academic Publishers.

引用

页码：659 / 665

页数：6

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