Impact of metabolic syndrome on the incidence of type 2 diabetes in middle-aged Japanese individuals with impaired insulin secretion: the Saku study

被引：0
作者：
Morimoto A. [1 ]
Tatsumi Y. [2 ]
Sonoda N. [3 ]
Miyamatsu N. [1 ]
Shimoda T. [4 ]
Sakaguchi S. [4 ]
机构：
[1] Department of Clinical Nursing, Shiga University of Medical Science, Tsukinowa-cho Seta, Otsu, 520-2192, Shiga
[2] Department of Hygiene and Public Health, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, 173-8605, Tokyo
[3] Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, 565-0871, Osaka
[4] Saku Central Hospital, 197 Usuda, Saku, 384-0301, Nagano
来源：
Diabetology International | 2017年 / 8卷 / 1期
基金：
日本学术振兴会;
关键词：
Impaired insulin secretion; Metabolic syndrome; Middle age; Type; 2; diabetes;
D O I：
10.1007/s13340-016-0287-6
中图分类号：
学科分类号：
摘要：
Aims: To assess the impact of metabolic syndrome (MetS) on the incidence of type 2 diabetes in middle-aged Japanese individuals with impaired insulin secretion (IIS). Methods: This cohort study included 1,702 individuals aged 40–59 without diabetes at baseline who underwent a comprehensive medical check-up between April 2008 and March 2009 at Saku Central Hospital. Participants were classified according to their IIS and insulin resistance (IR) status [normal, isolated IR (i-IR), or isolated IIS (i-IIS)] and MetS (presence or absence). They were followed up until March 2014. Type 2 diabetes was defined based on fasting and 2-h post-load plasma glucose concentrations and by the receipt of medical treatment for diabetes. Results: During 7,572 person-years of follow-up, 92 individuals developed type 2 diabetes. The incidence rates (/1,000 person-years) for type 2 diabetes in the normal without MetS, normal with MetS, i-IR without MetS, i-IR with MetS, i-IIS without MetS, and i-IIS with MetS groups were 5.3, 3.7, 11.3, 24.7, 16.7, and 59.5, respectively. The multivariable-adjusted hazard ratios (HRs) and 95 % confidence intervals (CIs) for type 2 diabetes in the normal with MetS, i-IR with MetS, and i-IIS with MetS groups, relative to the normal without MetS group, were 0.52 (0.12–2.25), 3.78 (1.93–7.42), and 7.94 (3.96–15.91), respectively. Additionally, a positive association of MetS with type 2 diabetes was observed in the i-IIS group [HR (95 % CI) 3.56 (1.88–6.73)] but not in the normal and i-IR groups. Conclusions: The prevention of MetS is important, particularly in individuals with low insulin secretion. © 2016, The Japan Diabetes Society.
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页码：104 / 111
页数：7
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