Preparation of Chitosan microspheres containing 166Dy/166Ho in vivo generators and their theranostic potential

被引：0
作者：
Bo-Bae Cho
Kanghyuk Choi
机构：
[1] Korea Atomic Energy Research Institute,
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2018年 / 317卷
关键词：
Chitosan microspheres; In vivo generator; Dysprosium-166; Holmium-166;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chitosan microsphere (MS) loaded with 166Dy/166Ho were designed for therapy of unresectable liver tumor through an in vivo generator system. The mean size of the MS was affected by the stirring rate, concentration of emulsifier and cross-linking agent. The MS have ability to absorb water and ethanol to swell to eightfold their original volume. Importantly, approximately 53.89% ± 2.44 of 166Dy was absorbed into the MS to release in human serum about 8% of the absorbed amount. The advantages of high absorption and low release rate show these MS promising as a potential carrier of an in vivo generator system.
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页码：1123 / 1132
页数：9
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