Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells

Amos CI(2006)Distributions of five common point mutants in the human tracheal-bronchial epithelium Mutat Res 596 a026179-2559

Wei Q(2016)Somatic TP53 Mutations in the Era of Genome Sequencing Cold Spring Harb Perspect Med 6 8-10743

Wu X(1999)Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer J Pathol 187 415-82

Hussain SP(2013)Signatures of mutational processes in human cancer Nature. 500 1033-71

Amstad P(2012)Assuring the quality of next-generation sequencing in clinical laboratory practice Nat Biotechnol 30 1-575

Raja K(2019)Orthogonal comparison of four plasma NGS tests with tumor suggests technical factors are a major source of assay discordance Jco Precision Oncology 3 537-1277

Sawyer M(2016)Haplotype and diplotype analyses of variation in ERCC5 transcription cis-regulation in normal bronchial epithelial cells Physiol Genomics 48 8629-31718

Hofseth L(2009)Pattern of antioxidant and DNA repair gene expression in normal airway epithelium associated with lung cancer diagnosis Cancer Res 69 2552-1316

Shields PG(2007)CEBPG regulates ERCC5/XPG expression in human bronchial epithelial cells and this regulation is modified by E2F1/YY1 interactions Carcinogenesis. 28 10727-undefined

Steiling K(2016)Adaptive upregulation of DNA repair genes following benzo(a) pyrene diol epoxide protects against cell death at the expense of mutations Nucleic Acids Res 44 77-undefined

Amos CI(2006)Distributions of five common point mutants in the human tracheal-bronchial epithelium Mutat Res 596 a026179-2559

Wei Q(2016)Somatic TP53 Mutations in the Era of Genome Sequencing Cold Spring Harb Perspect Med 6 8-10743

Wu X(1999)Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer J Pathol 187 415-82

Hussain SP(2013)Signatures of mutational processes in human cancer Nature. 500 1033-71

Amstad P(2012)Assuring the quality of next-generation sequencing in clinical laboratory practice Nat Biotechnol 30 1-575

Raja K(2019)Orthogonal comparison of four plasma NGS tests with tumor suggests technical factors are a major source of assay discordance Jco Precision Oncology 3 537-1277

Sawyer M(2016)Haplotype and diplotype analyses of variation in ERCC5 transcription cis-regulation in normal bronchial epithelial cells Physiol Genomics 48 8629-31718

Hofseth L(2009)Pattern of antioxidant and DNA repair gene expression in normal airway epithelium associated with lung cancer diagnosis Cancer Res 69 2552-1316

Shields PG(2007)CEBPG regulates ERCC5/XPG expression in human bronchial epithelial cells and this regulation is modified by E2F1/YY1 interactions Carcinogenesis. 28 10727-undefined

Steiling K(2016)Adaptive upregulation of DNA repair genes following benzo(a) pyrene diol epoxide protects against cell death at the expense of mutations Nucleic Acids Res 44 77-undefined