Study of the Effect of Bisphenol A on Oxidative Stress in Children with Autism Spectrum Disorders

被引：26

作者：

Metwally F.M. ^{[1
]}

Rashad H. ^{[1
]}

Zeidan H.M. ^{[2
]}

Kilany A. ^{[2
]}

Abdol Raouf E.R. ^{[2
]}

机构：

[1] Environmental Research Division, Occupational and Environmental Medicine Department, National Research Centre, Cairo

[2] Medical Research Division, Research on Children with Special Needs Department, National Research Centre, Cairo

来源：

Indian Journal of Clinical Biochemistry | 2018年 / 33卷 / 2期

关键词：

8-Hydroxydeoxyguanosine; Autism; Bisphenol A; Oxidative stress;

D O I：

10.1007/s12291-017-0667-0

中图分类号：

学科分类号：

摘要：

The role of bisphenol A (BPA) in autism was investigated in 49 children (mean age = 5.950 ± 1.911 years) with autism spectrum disorders (ASDs) and 40 comparable age and sex matched children used as controls (mean age = 5.333 ± 2.279 years). In addition, 8-Hydroxydeoxyguanosine (8-oxodG) was also studied as a biomarker of oxidative stress in the same set of two selected groups. The results showed that both BPA and 8-oxodG were significantly higher in children with autism than those of control children (p values = 0.025 and 0.0001, respectively). There were positive correlations between both BPA and 8-oxodG with ASDs severity (r = 0.400 and 0.805, respectively), these correlations were highly significant (p values = 0.004 and 0.001, respectively). There was a significance positive correlation between BMI and BPA, but the correlation between BMI and 8-oxodG was not significant in children with autism. The observed results revealed that BPA may increase oxidative stress resulting in mitochondrial dysfunction that affecting the behavior and functioning of ASDs children. © 2017, Association of Clinical Biochemists of India.

引用

页码：196 / 201

页数：5

共 30 条

[1]

Makris K.C., Andra S.S., Jia A., Herrick L., Christophi C.A., Snyder S.A., Et al., Association between water consumption from polycarbonate containers and bisphenol A intake during harsh environmental conditions in summer, Environ Sci Technol, 47, pp. 3333-3343, (2013)

[2]

Vandenberg L.N., Hauser R., Marcus M., Olea N., Welshons W.V., Human exposure to bisphenol A (BPA), Reprod Toxicol, 24, 2, pp. 139-177, (2007)

[3]

Rochester J.R., Bisphenol A and human health: a review of the literature, Reprod Toxicol, 42, pp. 132-155, (2013)

[4]

Kardas F., Bayram A.K., Demirci E., Akin L., Ozmen S., Kendirci M., Et al., Increased serum phthalates (MEHP, DEHP) and bisphenol a concentrations in children with autism spectrum disorder: the role of endocrine disruptors in autism etiopathogenesis, J Child Neurol, 31, 5, pp. 629-635, (2016)

[5]

Stein T.P., Schluter M.D., Steer R.A., Guo L., Ming X., Bisphenol A exposure in children with autism spectrum disorders, Autism Res, 8, pp. 272-283, (2015)

[6]

Miodovnik A., Engel S.M., Canfield R.L., Zhu C., Silva M.J., Calafat A.M., Et al., Enodcrine disruptors and childhood social impairment, Neurotoxicology, 32, pp. 261-267, (2011)

[7]

Larsson M., Weiss B., Janson S., Sundell J., Bornehag C.G., Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6–8 years of age, Neurotoxicology, 30, pp. 822-831, (2009)

[8]

Szychowski K.A., Ak W., Components of plastic disrupt the function of the nervous system, Poste¸py Higieny Imedycyny Do´swiadczalnej, 67, pp. 499-506, (2013)

[9]

Xu X., Xie L., Hong X., Et al., Perinatal exposure to bisphenol-A inhibits synaptogenesis and affects the synaptic morphological development in offspring male mice, Chemosphere, 91, 8, pp. 1073-1081, (2013)

[10]

Diagnostic and Statistical Manual of Mental Disorders, (1994)

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