Pregnancy-associated plasma protein A – a new indicator of pulmonary vascular remodeling in chronic thromboembolic pulmonary hypertension?

[1] Wilkens H(2018)Chronic thromboembolic pulmonary hypertension (CTEPH): updated recommendations from the Cologne Consensus Conference 2018 Int J Cardiol 272 69-78

[2] Konstantinides S(2018)N-terminal pro-B-type natriuretic peptide for monitoring after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension J Heart Lung Transplant 37 639-646

[3] Lang IM(1999)The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A Proc Natl Acad Sci U S A 96 3149-3153

[4] Kriechbaum SD(2011)Serum pregnancy-associated plasma protein A in patients with heart failure J Card Fail 17 819-826

[5] Wiedenroth CB(2014)New insights into IGF-1 signaling in the heart Trends Endocrinol Metab 25 128-137

[6] Wolter J-SS(2012)Downstream insulin-like growth factor Endocr Dev 23 42-51

[7] Lawrence JB(2015)IGF-1 signaling in neonatal hypoxia-induced pulmonary hypertension: role of epigenetic regulation Vasc Pharmacol 73 20-31

[8] Oxvig C(2016)Smooth muscle insulin-like growth factor-1 mediates hypoxia-induced pulmonary hypertension in neonatal mice Am J Respir Cell Mol Biol 55 779-791

[9] Overgaard MT(2007)Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet Circ Res 100 1696-1702

[10] Funayama A(2015)A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts Mol Cancer Ther 14 973-981

[1] Wilkens H(2018)Chronic thromboembolic pulmonary hypertension (CTEPH): updated recommendations from the Cologne Consensus Conference 2018 Int J Cardiol 272 69-78

[2] Konstantinides S(2018)N-terminal pro-B-type natriuretic peptide for monitoring after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension J Heart Lung Transplant 37 639-646

[3] Lang IM(1999)The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A Proc Natl Acad Sci U S A 96 3149-3153

[4] Kriechbaum SD(2011)Serum pregnancy-associated plasma protein A in patients with heart failure J Card Fail 17 819-826

[5] Wiedenroth CB(2014)New insights into IGF-1 signaling in the heart Trends Endocrinol Metab 25 128-137

[6] Wolter J-SS(2012)Downstream insulin-like growth factor Endocr Dev 23 42-51

[7] Lawrence JB(2015)IGF-1 signaling in neonatal hypoxia-induced pulmonary hypertension: role of epigenetic regulation Vasc Pharmacol 73 20-31

[8] Oxvig C(2016)Smooth muscle insulin-like growth factor-1 mediates hypoxia-induced pulmonary hypertension in neonatal mice Am J Respir Cell Mol Biol 55 779-791

[9] Overgaard MT(2007)Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet Circ Res 100 1696-1702

[10] Funayama A(2015)A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts Mol Cancer Ther 14 973-981