Antimicrobial susceptibility pattern of Staphylococcus aureus isolates from clinical specimens at Kenyatta National Hospital

被引：35

作者：

Gitau W. ^{[1
]}

Masika M. ^{[1
]}

Musyoki M. ^{[1
]}

Museve B. ^{[2
]}

Mutwiri T. ^{[3
]}

机构：

[1] Department of Medical Microbiology, University of Nairobi, P.O Box 19676-00202, Nairobi

[2] Department of Laboratory Medicine, Microbiology, Kenyatta National Hospital, P.O Box 20723-00202, Nairobi

[3] Department of Medical Laboratory, Kenya Methodist University, P.O Box 45240-00100, Nairobi

来源：

BMC Research Notes | / 11卷 / 1期

关键词：

Drug resistance; Kenyatta National Hospital; Methicillin resistant Staphylococcus aureus; Staphylococcus aureus; Susceptibility; Vancomycin;

D O I：

10.1186/s13104-018-3337-2

中图分类号：

学科分类号：

摘要：

Objective: To determine antibiotic susceptibility pattern of S. aureus isolates from clinical specimens collected from patients at Kenyatta National Hospital from March 2014-February 2016, and to determine the prevalence and quarterly trends of MRSA throughout the study period. Results: A total of 944 S. aureus isolates were analyzed. High sensitivity of S. aureus was observed for quinupristin/dalfopristin (100%), tigecycline (98.2), imipenem (98%), nitrofurantoin (97.6%), linezolid (97.3%), teicoplanin (97.1%) and vancomycin (95.1%). High resistance was recorded against penicillin G (91.9%), trimethoprim/sulfamethoxazole (56.9%) and tetracycline (33.2%). MRSA prevalence among the patients at KNH was 27.8%. Highest proportion (80%) of MRSA was in burns unit. Both MRSA and MSSA were highly susceptible to quinupristin/dalfopristin, tigecycline, linezolid, nitrofurantoin, ampicillin/sulbactam and vancomycin and showed high resistance to commonly used antibiotics such as gentamycin, erythromycin, levofloxacin and tetracycline. A majority of isolates were from pus specimen (68%). © 2018 The Author(s).

引用

共 26 条

[1]

Pantosti A., Sanchini A., Monaco M., Mechanisms of antibiotic resistance in Staphylococcus aureus, Future Microbiol, 2, pp. 323-334, (2007)

[2]

Loomba P.S., Taneja J., Mishra B., Methicillin and vancomycin resistant S. Aureus in hospitalized patients, J. Glob Infect Dis., 2, pp. 275-283, (2010)

[3]

Espedido B.A., Gosbell I.B., Chromosomal mutations involved in antibiotic resistance in Staphylococcus aureus, Front Biosci., 4, pp. 900-915, (2012)

[4]

Kumar M., Multidrug-resistant Staphylococcus aureus, India, 2013-2015, Emerg Infect Dis, 22, pp. 1666-1667, (2016)

[5]

Maina E.K., Kiiyukia C., Wamae C.N., Waiyaki P.G., Kariuki S., Characterization of methicillin-resistant Staphylococcus aureus from skin and soft tissue infections in patients in Nairobi, Kenya, Int J Infect Dis, 17, pp. e115-e119, (2013)

[6]

Aiken A.M., Mutuku I.M., Sabat A.J., Akkerboom V., Mwangi J., Scott J.A.G., Et al., Carriage of Staphylococcus aureus in Thika Level 5 Hospital, Kenya: A cross-sectional study, Antimicrob Resist Infect Control., 3, (2014)

[7]

Israel G.D., Determining Sample Size 1, pp. 1-5, (1992)

[8]

Kanaga E.L., Antimicrobial Susceptibility of Bacteria That Cause Wound Sepsis in the Paediatric Surgical Patients at Kenyatta National Hospital, (2014)

[9]

Soltani R., Khalili H., Rasoolinejad M., Abdollahi A., Antimicrobial susceptibility pattern of Staphylococcus aureus strains isolated from hospitalized patients in Tehran, Iran, Iran J Pharm Sci., 6, pp. 125-132, (2010)

[10]

Obiazi H.A.K., Ekundayo A.O., Ukwandu N.C.D., Prevalence and antibiotic susceptibility pattern of Staphylococcus aureus from clinical isolates grown at 37 and 44 °c from Irrua, Nigeria, African J Microbiol Res., 1, pp. 57-60, (2007)

← 1 2 3 →