The role of the addition of ovarian suppression to tamoxifen in young women with hormone-sensitive breast cancer who remain premenopausal or regain menstruation after chemotherapy (ASTRRA): study protocol for a randomized controlled trial and progress

被引：0

作者：

Hyun-Ah Kim

Sei Hyun Ahn

Seok Jin Nam

Seho Park

Jungsil Ro

Seock-Ah Im

Yong Sik Jung

Jung Han Yoon

Min Hee Hur

Yoon Ji Choi

Soo-Jung Lee

Joon Jeong

Se-Heon Cho

Sung Yong Kim

Min Hyuk Lee

Lee Su Kim

Byung-In Moon

Tae Hyun Kim

Chanheun Park

Sei Joong Kim

Sung Hoo Jung

Heungkyu Park

Geum Hee Gwak

Sun Hee Kang

Jong Gin Kim

Jeryong Kim

Su Yun Choi

Cheol-Wan Lim

Doyil Kim

Youngbum Yoo

Young-Jin Song

Yoon-Jung Kang

Sang Seol Jung

Hyuk Jai Shin

Kwan Ju Lee

Se-Hwan Han

Eun Sook Lee

Wonshik Han

Hee-Jung Kim

Woo Chul Noh

机构：

[1] Korea Cancer Center Hospital,Department of Surgery

[2] Korea Institute of Radiological and Medical Sciences,Department of Surgery

[3] University of Ulsan,Department of Surgery

[4] Asan Medical Center,Department of Surgery

[5] Samsung Medical Center,Department of Internal Medicine

[6] Sungkyunkwan University School of medicine,Department of Surgery

[7] Yonsei University College of Medicine,Department of Surgery

[8] Center for Breast Cancer,Department of Surgery

[9] National Cancer Center,Department of Internal Medicine

[10] Seoul National University Hospital,Department of Surgery

[11] Cancer Research Institute,Department of Surgery

[12] Seoul National University College of Medicine,Department of Surgery

[13] Ajou University,Department of Surgery

[14] School of Medicine,Department of Surgery

[15] Chonnam National University Hwasun Hospital,Division of Breast & Endocrine Surgery

[16] Cheil General Hospital and Women’s Healthcare Center,Department of Surgery

[17] Dankook University College of Medicine,Department of Surgery

[18] Korea University Anam Hospital,Department of Surgery

[19] Yeungnam University Hospital,Department of Surgery

[20] Gangnam Severance Hospital,Department of Surgery

[21] Yonsei University,Department of Breast Surgery

[22] Dong-A University Hospital,Department of Surgery

[23] Soonchunhyang University College of Medicine,Department of Surgery

[24] Cheonan Hospital,Departments of Surgery

[25] Soonchunhyang University Colleage of Medicine,Department of Surgery

[26] Hallym University Sacred Heart Hospital,Department of Surgery

[27] College of Medicine,Department of Surgery

[28] Hallym University,Department of Surgery

[29] Mokdong Hospital,Department of Surgery

[30] Ewha Womans University,Department of Surgery

[31] Inje University Busan Paik Hospital,Department of Surgery

[32] Sungkyunkwan University School of Medicine,Department of Surgery

[33] Kangbuk Samsung Hospital,Breast and thyroid care center, Department of Surgery

[34] Inha University Hospital,Department of Surgery

[35] Inha University,Department of Surgery and Cancer Research Institute

[36] Chonbuk National University Medical School,undefined

[37] Gachon University Gil Hospital,undefined

[38] Inje University Sanggye Paik Hospital,undefined

[39] Inje University College of Medicine,undefined

[40] Keimyung University School of Medicine,undefined

[41] Seoul National University Boramae Medical Center,undefined

[42] Chungnam National University Hospital,undefined

[43] KangDong sacred heart hospital,undefined

[44] Hallym university,undefined

[45] Soonchunhyang University College of Medicine,undefined

[46] Bucheon Hospital,undefined

[47] Kangseo Mizmedi Hospital,undefined

[48] Konkuk University School of Medicine,undefined

[49] Chungbuk National University College of Medicine and Medical Research Institute,undefined

[50] Eulji University Hospital,undefined

来源：

BMC Cancer | / 16卷

关键词：

Ovarian function suppression; Goserelin; Tamoxifen; Adjuvant endocrine therapy; Premenopause; Breast cancer;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 101 条

[1] Fisher B(1996)Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors J Natl Cancer Inst 88 1529-42
[2] Dignam J(2005)Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials Lancet 365 1687-717
[3] Bryant J(2004)Treatment of lymph-node-negative, oestrogen-receptor-positive breast cancer: long-term findings from National Surgical Adjuvant Breast and Bowel Project randomised clinical trials Lancet 364 858-68
[4] DeCillis A(1994)The influence of young age on outcome in early stage breast cancer Int J Radiat Oncol Biol Phys 30 23-33
[5] Wickerham DL(2007)Poor outcome of hormone receptor-positive breast cancer at very young age is due to tamoxifen resistance: nationwide survival data in Korea--a report from the Korean Breast Cancer Society J Clin Oncol 25 2360-8
[6] Wolmark N(2015)Adjuvant ovarian suppression in premenopausal breast cancer N Engl J Med 372 436-46
[7] Fisher B(2014)The basic facts of korean breast cancer in 2011: results of a nationwide survey and breast cancer registry database J Breast Cancer 17 99-106
[8] Jeong J(2002)Randomized adjuvant trial of tamoxifen and goserelin versus cyclophosphamide, methotrexate, and fluorouracil: evidence for the superiority of treatment with endocrine blockade in premenopausal patients with hormone-responsive breast cancer--Austrian Breast and Colorectal Cancer Study Group Trial 5 J Clin Oncol 20 4621-7
[9] Bryant J(2007)Adjuvant chemotherapy followed by goserelin compared with either modality alone: the impact on amenorrhea, hot flashes, and quality of life in premenopausal patients--the International Breast Cancer Study Group Trial VIII J Clin Oncol 25 263-70
[10] Anderson S(2007)Use of luteinising-hormone-releasing hormone agonists as adjuvant treatment in premenopausal patients with hormone-receptor-positive breast cancer: a meta-analysis of individual patient data from randomised adjuvant trials Lancet 369 1711-23

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