Malignant peripheral nerve sheath tumor in a patient with Werner's syndrome

被引：0

作者：

M. A. Rosa

G. Falcone

V. De Santis

O. Azzaro

机构：

[1] Orthopaedics Department, University of Messina, I-98100 Messina, Via Consolare Valeria

来源：

Journal of Orthopaedics and Traumatology | 2003年 / 4卷 / 2期

关键词：

MPNST; Soft tissue sarcomas; Tumor; Werner;

D O I：

10.1007/s10195-003-0018-1

中图分类号：

学科分类号：

摘要：

Werner's syndrome is a rare autosomal recessive disorder characterized by features of premature aging. It is attributed to an autosomal recessive mutation on chromosome 8p12 where the Werner gene is located. This gene encodes a protein homologous to the RecQ-type DNA helicase, an enzyme that unwinds double-stranded DNA into single-stranded DNA. The association of Werner's syndrome with malignant tumors is widely reported in the literature. Both bone and soft tissue sarcomas have been described. We report a patient with Werner's syndrome who developed a malignant peripheral nerve sheath tumor of the left popliteal fossa.

引用

页码：95 / 99

页数：4

共 15 条

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