TIE1 and TEK signalling, intraocular pressure, and primary open-angle glaucoma: a Mendelian randomization study

[1] Weinreb RN(2016)Primary open-angle glaucoma Nat Rev Dis Primers 2 16067-351

[2] Leung CK(2022)Time trends, associations and prevalence of blindness and vision loss due to glaucoma: an analysis of observational data from the Global Burden of Disease Study 2017 BMJ Open 12 348-10349

[3] Crowston JG(2022)endothelial tyrosine kinase tie1 is required for normal schlemm's canal development-brief report Arterioscler Thromb Vasc Biol 42 6072-4324

[4] Sun Y(2021)Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies Nat Commun 12 10339-30517

[5] Chen A(2020)Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis Proc Natl Acad Sci U S A 117 4320-4381

[6] Zou M(2014)A lymphatic defect causes ocular hypertension and glaucoma in mice J Clin Invest 124 30509-2587

[7] Du J(2007)Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2 J Biol Chem 282 4376-3896

[8] Thomson BR(2017)Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization Proc Natl Acad Sci U S A 114 2575-782

[9] Onay T(2016)Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity J Clin Invest 126 3877-22

[10] Quaggin SE(2017)Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma J Clin Invest 127 778-860

[1] Weinreb RN(2016)Primary open-angle glaucoma Nat Rev Dis Primers 2 16067-351

[2] Leung CK(2022)Time trends, associations and prevalence of blindness and vision loss due to glaucoma: an analysis of observational data from the Global Burden of Disease Study 2017 BMJ Open 12 348-10349

[3] Crowston JG(2022)endothelial tyrosine kinase tie1 is required for normal schlemm's canal development-brief report Arterioscler Thromb Vasc Biol 42 6072-4324

[4] Sun Y(2021)Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies Nat Commun 12 10339-30517

[5] Chen A(2020)Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis Proc Natl Acad Sci U S A 117 4320-4381

[6] Zou M(2014)A lymphatic defect causes ocular hypertension and glaucoma in mice J Clin Invest 124 30509-2587

[7] Du J(2007)Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2 J Biol Chem 282 4376-3896

[8] Thomson BR(2017)Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization Proc Natl Acad Sci U S A 114 2575-782

[9] Onay T(2016)Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity J Clin Invest 126 3877-22

[10] Quaggin SE(2017)Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma J Clin Invest 127 778-860