Characteristics of Gastric Cancer in Lebanon: a Descriptive Study from a Single Institutional Experience

被引：6
作者：
Assi T. [1 ]
El Rassy E. [1 ]
Khazzaka A. [2 ]
Moussa T. [3 ]
Ibrahim T. [1 ]
Kattan C. [1 ]
El Karak F. [1 ]
Farhat F. [1 ]
Ghosn M. [1 ]
Kattan J. [1 ]
机构：
[1] Department of Oncology, Hotel Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut
[2] Surgical Research Laboratory, Faculty of Medicine, Saint Joseph University, Beirut
[3] Department of Radiology, Hotel Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut
来源：
Journal of Gastrointestinal Cancer | 2018年 / 49卷 / 1期
关键词：
Diffuse histology; Gastric cancer; HER2; Lebanon; Middle East;
D O I：
10.1007/s12029-016-9903-8
中图分类号：
学科分类号：
摘要：
Background: The epidemiology of gastric cancer in the Middle East has never been described. Therefore, the characteristics of gastric cancer in the Lebanese population will be reported in this study. Patients and Methods: A retrospective study that included all patients diagnosed with gastric cancer at Hotel Dieu de France University Hospital in Beirut, Lebanon between 2010 and 2016 was conducted. All eligible patients were reviewed for demographic and epidemiologic analysis. Results: The study included 123 patients diagnosed with gastric cancer. The median age at diagnosis was 59 years (range 15–72 years), and the median ECOG performance status was 2 (range 1–4). Most patients were metastatic at diagnosis (52.8%), and diffuse pathology type was predominant (39%). HER2 was positive in 16.2% and correlated with the occurrence of hepatic metastasis (p = 0.048). The HER2 status did not differ significantly between the histological subtypes, the site of the tumor, the stage of the gastric cancer at diagnosis, and the recurrence of cancer (p > 0.05). Conclusion: Gastric cancer in the Lebanese population is characterized by aggressive features such as advanced stage at diagnosis, high prevalence of diffuse type histology, and HER2 positivity. © 2016, Springer Science+Business Media New York.
引用
收藏
页码：21 / 24
页数：3
相关论文
共 25 条
[1]  
Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Et al., Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012, Int J Cancer, 136, 5, pp. E359-E386, (2015)
[2]  
Bertuccio P., Chatenoud L., Levi F., Praud D., Ferlay J., Negri E., Et al., Recent patterns in gastric cancer: a global overview, Int J Cancer, 125, 3, pp. 666-673, (2009)
[3]  
Boku N., HER2-positive gastric cancer, Gastric Cancer Off J Int Gastric Cancer Assoc Jpn Gastric Cancer Assoc, 17, 1, pp. 1-12, (2014)
[4]  
Lebanese National Cancer Registry - 2008 [Internet], (2016)
[5]  
Wu H., Rusiecki J.A., Zhu K., Potter J., Devesa S.S., Stomach carcinoma incidence patterns in the United States by histologic type and anatomic site, Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol, 18, 7, pp. 1945-1952, (2009)
[6]  
Ferro A., Peleteiro B., Malvezzi M., Bosetti C., Bertuccio P., Levi F., Et al., Worldwide trends in gastric cancer mortality (1980-2011), with predictions to 2015, and incidence by subtype, Eur J Cancer Oxf Engl 1990, 50, 7, pp. 1330-1344, (2014)
[7]  
Mabula J.B., Mchembe M.D., Koy M., Chalya P.L., Massaga F., Rambau P.F., Et al., Gastric cancer at a university teaching hospital in northwestern Tanzania: a retrospective review of 232 cases, World J SurgOncol, 10, (2012)
[8]  
Shan L., Ying J., Lu N., HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population, Diagn Pathol, 8, (2013)
[9]  
Chua T.C., Merrett N.D., Clinicopathologic factors associated with HER2-positive gastric cancer and its impact on survival outcomes—a systematic review, Int J Cancer, 130, 12, pp. 2845-2856, (2012)
[10]  
Mohammed A.A., Al-Zahrani A.S., El-Kashif A.T., P0022 clinicopathological features of gastric cancer: a single-centre experience, Eur J Cancer, 50, (2014)
123