Investigation of Inflammatory and Hemostatic Parameters in Female Patients Undergoing Total Knee Arthroplasty Surgery

被引：0
作者：
A. Ata Alturfan
Levent Eralp
Nesrin Emekli
机构：
[1] Cerrahpasa Medical Faculty,Vocational School Health Services
[2] Istanbul University,Department of Orthopaedics and Traumatology
[3] Istanbul University Medical Faculty,Department of Biochemistry, School of Dentistry
[4] Marmara University,undefined
来源：
Inflammation | 2008年 / 31卷
关键词：
osteoarthritis; inflammation; coagulation; galectin-3; tissue factor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Tendency to hypercoagulation is a common phenomenon in primary osteoarthritis patients (POA) undergoing total knee arthroplasty (TKA) surgery, but the clinical implications of this condition are not clear. Therefore we aimed to evaluate the inflammatory and coagulation parameters in the patient group and find a possible explanation for the tendency to hypercoagulation occurring in plasma and synovia of inflamed joints. Of the evaluated factors involved in inflammation and coagulation, galectin-3, C reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, FVIIa:C, FXII:C, and platelet count increased, whereas tissue factor (TF) activity in synovia, PT, APTT and FVII:C in plasma and synovia were decreased. In conclusion, activation of inflammation and tendency to hypercoagulation is observed in preoperative plasma and synovia of patients undergoing TKA surgery.
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页码：414 / 421
页数：7
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