Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells

被引：0
作者：
V. Kh. Khavinson
N. S. Linkova
I. M. Kvetnoy
V. O. Polyakova
A. O. Drobintseva
T. V. Kvetnaia
O. M. Ivko
机构：
[1] St. Petersburg Institute of Bioregulation and Gerontology,Department of Biogerontology
[2] Russian Academy of Sciences,Group of Peptide Regulation and Aging, I. P. Pavlov Institute of Physiology
[3] Academy of Postgraduate Education under Federal Research Clinical Center of Federal Medical-Biological Agency of Russia,Department of Therapy, Geriatrics, and Anti
来源：
Bulletin of Experimental Biology and Medicine | 2020年 / 170卷
关键词：
thymalin; peptides; hematopoietic stem cells; cell differentiation; COVID-19;
D O I：
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摘要：
Thymalin is a polypeptide complex isolated from the thymus and regulating the functions of the immune system. Thymalin is effective in therapy of acute respiratory syndrome, chronic obstructive bronchitis, and other immunopathology. Thymalin increases functional activity of T lymphocytes, but the targeted molecular mechanism of its biological activity requires further study. We studied the influence of thymalin on differentiation of human hematopoietic stem cells (HSC) and expression of CD28 molecule involved in the implementation of antiviral immunity in COVID-19 infection. It was found that thymalin reduced the expression of CD44 (stem cell marker) and CD117 (molecule of the intermediate stage of HSC differentiation) by 2-3 times and increased the expression of CD28 (marker of mature T lymphocytes) by 6.8 times. This indirectly indicates that thymalin stimulated differentiation of CD117+ cells into mature CD28+T lymphocytes. It is known that in patients with severe COVID-19, the number of CD28+, CD4+, CD8+T lymphocytes in the blood decreased, which attested to a pronounced suppression of immunity. It is possible that the antiviral effect of thymalin consists in compensatory stimulation of HSC differentiation into CD28+T lymphocytes at the stage of immunity suppression in unfavorable course of viral infection. Thymalin can be considered as an immunoprotective peptide drug for the prevention of COVID-19.
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页码：118 / 122
页数：4
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