Synthesis and structure of tricyclic quinazoline alkaloid oxalates

被引：0

作者：

A. G. Tozhiboev

K. K. Turgunov

B. Tashkhodzhaev

Kh. M. Shakhidoyatov

机构：

[1] Academy of Sciences of the Republic of Uzbekistan,S. Yu. Yunusov Institute of the Chemistry of Plant Substances

来源：

Chemistry of Natural Compounds | 2007年 / 43卷

关键词：

deoxyvasicinone; 2,3-tetra-,-pentamethylene-3,4-dihydroquinazol-4-one; oxalates; x-ray crystal structure; complexes; protonation; H-bonds;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Oxalates of the alkaloids deoxyvasicinone, 2,3-tetra-, and their seven-membered analog 2,3-pentamethylen-3,4-dihydroquinazol-4-one and the complex of 2,3-pentamethylen-3,4-dihydroquinazol-4-one hydrochloride with oxalic acid were synthesized. It was found that 2:1, 2:1, and 1:1 alkaloid:oxalic acid complexes, respectively, were formed. The last complex had 2,3-pentamethylen-3,4-dihydroquinazol-4-one, oxalic acid, and HCl in a 2:1:2 ratio, respectively. X-ray crystal structures of single crystals were performed. The oxalate of 2,3-pentamethylen-3,4-dihydroquinazol-4-one and its hydrochloride formed salts with a protonated N1 atom and involvement of only one hydroxyl. The other alkaloids formed a complex with oxalic acid through N1…H-O H-bonds involving both acid hydroxyls.

引用

页码：184 / 189

页数：5

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