Real-life use of vitamin D3-fortified bread and milk during a winter season: the effects of CYP2R1 and GC genes on 25-hydroxyvitamin D concentrations in Danish families, the VitmaD study

被引：0
作者：
Janna Nissen
Ulla Vogel
Gitte Ravn-Haren
Elisabeth W. Andersen
Bjørn A. Nexø
Rikke Andersen
Heddie Mejborn
Katja H. Madsen
Lone B. Rasmussen
机构：
[1] Technical University of Denmark,Division of Nutrition, National Food Institute
[2] National Research Centre for the Working Environment,Division of Toxicology and Risk Assessment, National Food Institute
[3] Technical University of Denmark,Department of Applied Mathematics and Computer Science
[4] Technical University of Denmark,Department of Biomedicine
[5] Aarhus University,undefined
来源：
Genes & Nutrition | 2014年 / 9卷
关键词：
SNPs; Vitamin D; 25-Hydroxyvitamin D; D; -fortification; Genetic risk score; Vitamin D insufficiency;
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摘要：
Common genetic variants rs10741657 and rs10766197 in CYP2R1 and rs4588 and rs842999 in GC and a combined genetic risk score (GRS) of these four variants influence late summer 25-hydroxyvitamin D (25(OH)D) concentrations. The objectives were to identify those who are most at risk of developing low vitamin D status during winter and to assess whether vitamin D3-fortified bread and milk will increase 25(OH)D concentrations in those with genetically determined low 25(OH)D concentrations at late summer. We used data from the VitmaD study. Participants were allocated to either vitamin D3-fortified bread and milk or non-fortified bread and milk during winter. In the fortification group, CYP2R1 (rs10741657) and GC (rs4588 and rs842999) were statistically significantly associated with winter 25(OH)D concentrations and CYP2R1 (rs10766197) was borderline significant. There was a negative linear trend between 25(OH)D concentrations and carriage of 0–8 risk alleles (p < 0.0001). No association was found for the control group (p = 0.1428). There was a significant positive linear relationship between different quintiles of total vitamin D intake and the increase in 25(OH)D concentrations among carriers of 0–2 (p = 0.0012), 3 (p = 0.0001), 4 (p = 0.0118) or 5 (p = 0.0029) risk alleles, but not among carriers of 6–8 risk alleles (p = 0.1051). Carriers of a high GRS were more prone to be vitamin D deficient compared to carriers of a low GRS. Furthermore, rs4588-AA carriers have a low but very stable 25(OH)D concentration, and interestingly, also low PTH level.
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  • [1] Abbas S(2008)The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status Cancer Epidemiol Biomarkers Prev 17 1339-1343
  • [2] Linseisen J(2010)Genome-wide association study of circulating vitamin D levels Hum Mol Genet 19 2739-2745
  • [3] Slanger T(2005)Teenage girls and elderly women living in northern Europe have low winter vitamin D status Eur J Clin Nutr 59 533-541
  • [4] Ahn J(1993)Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP) Hum Genet 92 183-188
  • [5] Yu K(1986)Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein J Clin Endocrinol Metab 63 954-959
  • [6] Stolzenberg-Solomon R(2010)Vitamin D production after UVB exposure depends on baseline vitamin D and total cholesterol but not on skin pigmentation J Invest Dermatol 130 546-553
  • [7] Andersen R(2009)Vitamin D in health and disease: an insight into traditional functions and new roles for the “sunshine vitamin” Nutr Res Rev 22 118-136
  • [8] Mølgaard C(2010)Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects Hum Genet 128 549-556
  • [9] Skovgaard LT(2011)A systematic review and meta-regression analysis of the vitamin D intake-serum 25-hydroxyvitamin D relationship to inform European recommendations Br J Nutr 106 1638-1648
  • [10] Arnaud J(2004)Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase Proc Natl Acad Sci USA 101 7711-7715
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