Ceruloplasmin Protects Against Rotenone-Induced Oxidative Stress and Neurotoxicity

被引：0
作者：
Akiyo Hineno
Kazuma Kaneko
Kunihiro Yoshida
Shu-ichi Ikeda
机构：
[1] Shinshu University School of Medicine,Department of Medicine (Neurology and Rheumatology)
[2] Shinshu University School of Medicine,Division of Neurogenetics, Department of Brain Disease Research
来源：
Neurochemical Research | 2011年 / 36卷
关键词：
Ceruloplasmin; Iron; Rotenone; Oxidative stress; Antioxidant;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
To clarify the neuroprotective property of ceruloplasmin and the pathogenesis of aceruloplasminemia, we generated ceruloplasmin-deficient (CP−/−) mice on the C57BL/10 genetic background and further treated them with a mitochondrial complex I inhibitor, rotenone. There was no iron accumulation in the brains of CP−/− mice at least up to 60 weeks of age. Without rotenone treatment, CP−/− mice showed slight motor dysfunction compared with CP+/+ mice, but there were no detectable differences in the levels of oxidative stress markers between these two groups. A low dose of rotenone did not affect the mitochondrial complex I activity in our mice, however, it caused a significant change in motor behavior, neuropathology, or the levels of oxidative stress markers in CP−/− mice, but not in CP+/+ mice. Our data support that ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity, probably through its antioxidant properties independently of its function of iron metabolism.
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页码：2127 / 2135
页数：8
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