Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

被引:0
|
作者
Denise Martinez-Zapien
Francesc Xavier Ruiz
Juline Poirson
André Mitschler
Juan Ramirez
Anne Forster
Alexandra Cousido-Siah
Murielle Masson
Scott Vande Pol
Alberto Podjarny
Gilles Travé
Katia Zanier
机构
[1] Equipe labellisée Ligue,Department of Pathology
[2] Biotechnologie et signalisation cellulaire UMR 7242,undefined
[3] Ecole Superieure de Biotechnologie de Strasbourg,undefined
[4] Boulevard Sébastien Brant,undefined
[5] Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/INSERM U964/CNRS UMR 7104/Université de Strasbourg,undefined
[6] University of Virginia,undefined
来源
Nature | 2016年 / 529卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
WebStructural details of how oncogenic human papilloma viruses induce cancer by targeting the tumour suppressor p53 for ubiquitin-mediated degradation.
引用
收藏
页码:541 / 545
页数:4
相关论文
共 50 条
  • [1] Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53
    Martinez-Zapien, Denise
    Ruiz, Francesc Xavier
    Poirson, Juline
    Mitschler, Andre
    Ramirez, Juan
    Forster, Anne
    Cousido-Siah, Alexandra
    Masson, Murielle
    Vande Pol, Scott
    Podjarny, Alberto
    Trave, Gilles
    Zanier, Katia
    NATURE, 2016, 529 (7587) : 541 - +
  • [2] Association strength of E6 to E6AP/p53 complex correlates with HPV-mediated oncogenesis risk
    Ferreira Ferraz, Matheus Vitor
    Tabosa Viana, Isabelle Freire
    Coelho, Danilo Fernandes
    Bezerra da Cruz, Carlos Henrique
    Lima, Maira de Arruda
    de Luna Aragao, Madson Allan
    Lins, Roberto Dias
    BIOPOLYMERS, 2022, 113 (10)
  • [3] Structure of the E6/E6AP/p53 Complex in Human Papillomavirus
    Fassler, Amy
    Bhat, Tara
    Rens, Davis
    Chojnacki, Kennan
    Neil, Uma
    FASEB JOURNAL, 2020, 34
  • [4] Deciphering the mechanisms of HPV E6 mutations in the destabilization of E6/E6AP/p53 complex
    Li, Le
    Dong, Xuewei
    Tang, Yiming
    Lao, Zenghui
    Li, Xuhua
    Lei, Jiangtao
    Wei, Guanghong
    BIOPHYSICAL JOURNAL, 2022, 121 (09) : 1704 - 1714
  • [5] HPV E6 degradation of p53 and PDZ containing substrates in an E6AP null background
    Massimi, P.
    Shai, A.
    Lambert, P.
    Banks, L.
    ONCOGENE, 2008, 27 (12) : 1800 - 1804
  • [6] HPV E6 degradation of p53 and PDZ containing substrates in an E6AP null background
    P Massimi
    A Shai
    P Lambert
    L Banks
    Oncogene, 2008, 27 : 1800 - 1804
  • [7] Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation
    Li, Siying
    Hong, Xiaoling
    Wei, Zhentong
    Xie, Min
    Li, Wanying
    Liu, Guanchen
    Guo, Haoran
    Yang, Jiaxin
    Wei, Wei
    Zhang, Songling
    FRONTIERS IN MICROBIOLOGY, 2019, 10
  • [8] Felis catus papillomavirus type-2 E6 binds to E6AP, promotes E6AP/p53 binding and enhances p53 proteasomal degradation
    Altamura, Gennaro
    Power, Karen
    Martano, Manuela
    degli Uberti, Barbara
    Galiero, Giorgio
    De Luca, Giovanna
    Maiolino, Paola
    Borzacchiello, Giuseppe
    SCIENTIFIC REPORTS, 2018, 8
  • [9] Felis catus papillomavirus type-2 E6 binds to E6AP, promotes E6AP/p53 binding and enhances p53 proteasomal degradation
    Gennaro Altamura
    Karen Power
    Manuela Martano
    Barbara degli Uberti
    Giorgio Galiero
    Giovanna De Luca
    Paola Maiolino
    Giuseppe Borzacchiello
    Scientific Reports, 8
  • [10] Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53
    Cooper, B
    Schneider, S
    Bohl, J
    Jiang, YH
    Beaudet, A
    Vande Pol, S
    VIROLOGY, 2003, 306 (01) : 87 - 99