The structure of a virus-encoded nucleosome

被引：0
作者：
Marco Igor Valencia-Sánchez
Stephen Abini-Agbomson
Miao Wang
Rachel Lee
Nikita Vasilyev
Jenny Zhang
Pablo De Ioannes
Bernard La Scola
Paul Talbert
Steve Henikoff
Evgeny Nudler
Albert Erives
Karim-Jean Armache
机构：
[1] New York University Grossman School of Medicine,Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology
[2] New York University Grossman School of Medicine,Department of Biochemistry and Molecular Pharmacology
[3] Howard Hughes Medical Institute,Department of Biology
[4] Institut de Recherche Pour le Développement (IRD),undefined
[5] Assistance Publique – Hôpitaux de Marseille (AP-HM),undefined
[6] MEPHI,undefined
[7] Aix-Marseille University,undefined
[8] IHU Méditerranée Infection,undefined
[9] Basic Sciences Division,undefined
[10] Fred Hutchinson Cancer Research Center,undefined
[11] University of Iowa,undefined
来源：
Nature Structural & Molecular Biology | 2021年 / 28卷
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摘要：
Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form ‘forced’ heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.
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页码：413 / 417
页数：4
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