Cerenkov luminescence imaging (CLI) for image-guided cancer surgery

被引：70
作者：
Grootendorst M.R. [1 ,2 ]
Cariati M. [1 ,2 ]
Kothari A. [2 ]
Tuch D.S. [3 ]
Purushotham A. [1 ,2 ]
机构：
[1] Department of Research Oncology, 3rd Floor Bermondsey Wing, King’s College London, London
[2] Department of Breast Surgery, 3rd Floor Tower Wing, Guy’s Hospital, London
[3] Lightpoint Medical Ltd, The Island, Moor Road, Chesham
来源：
Clinical and Translational Imaging | 2016年 / 4卷 / 5期
基金：
“创新英国”项目;
关键词：
Cerenkov luminescence endoscopy; Cerenkov luminescence imaging; Image-guided surgery; Lymph nodes; Tumour margins;
D O I：
10.1007/s40336-016-0183-x
中图分类号：
学科分类号：
摘要：
Cerenkov luminescence imaging (CLI) is a novel molecular optical imaging technique based on the detection of optical Cerenkov photons emitted by positron emission tomography (PET) imaging agents. The ability to use clinically approved tumour-targeted tracers in combination with small-sized imaging equipment makes CLI a particularly interesting technique for image-guided cancer surgery. The past few years have witnessed a rapid increase in proof-of-concept preclinical studies in this field, and several clinical trials are currently underway. This article provides an overview of the basic principles of Cerenkov radiation and outlines the challenges of CLI-guided surgery for clinical use. The preclinical and clinical trial literature is examined including applications focussed on image-guided lymph node detection and Cerenkov luminescence endoscopy, and the ongoing clinical studies and technological developments are highlighted. By intraoperatively guiding the oncosurgeon towards more accurate and complete resections, CLI has the potential to transform current surgical practice, and improve oncological and cosmetic outcomes for patients. © 2016, The Author(s).
引用
收藏
页码：353 / 366
页数：13
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