The pathogenesis of renal injury and treatment in light chain deposition disease

被引:0
作者
Qi Wang
Fang Jiang
Gaosi Xu
机构
[1] The Second Affiliated Hospital of Nanchang University,Department of Nephrology
[2] Nanchang University,Medical Center of the Graduate School
[3] People’s Hospital of Xinyu City,Department of Nephrology
来源
Journal of Translational Medicine | / 17卷
关键词
Light chain deposition disease; Renal injury; Biopsy; Chemotherapy; Treatment;
D O I
暂无
中图分类号
学科分类号
摘要
Light chain deposition disease (LCDD) is a rare clinical disorder. The deposition of light chain immunoglobulins mainly affects the kidneys, which have different characteristics than other tissues. To date, the therapeutic approach for the treatment of LCDD has no evidence-based consensus, and clinical experience of reported cases guides current disease management strategies. The present systematic review investigates and summarizes the pathological mechanisms of renal injury and the subsequent treatments for LCDD.
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[1]  
Sayed RH(2015)Natural history and outcome of light chain deposition disease Blood 126 2805-2810
[2]  
Wechalekar AD(2012)Light chain deposition disease: novel biological insights and treatment advances Int J Lab Hematol 34 347-355
[3]  
Gilbertson JA(1976)Manifestations of systemic light chain deposition Am J Med 60 293-299
[4]  
Jimenez-Zepeda VH(2003)Light chain deposition disease with renal involvement: clinical characteristics and prognostic factors Am J Kidney Dis 42 1154-1163
[5]  
Randall RE(2001)Light chain deposition disease: a model of glomerulosclerosis defined at the molecular level Am Soc Nephrol 12 1558-1565
[6]  
Williamson WC(2001)Renal monoclonal immunoglobulin deposition disease: the disease spectrum Am Soc Nephrol 12 1482-1492
[7]  
Mullinax F(2007)Pathology of glomerular deposition diseases Pathol Int 57 551-565
[8]  
Pozzi C(1981)Early glomerular lesions in amyloidosis. Electronmicroscopic findings Virchows Arch A Pathol Anat Histol 390 259-272
[9]  
D’Amico M(1999)Glomerulopathic light chain–mesangial cell interactions modulate in vitro extracellular matrix remodeling and reproduce mesangiopathic findings documented in vivo Ultrastruct Pathol 23 107-126
[10]  
Fogazzi GB(2000)Renal manifestations of plasma cell dyscrasias: an appraisal from the patients’ bedside to the research laboratory Ann Diagn Pathol 4 174-200