Biotransformation of arsenic and toxicological implication of arsenic metabolites

被引：0
作者：
Seishiro Hirano
机构：
[1] National Institute for Environmental Studies,Center for Health and Environmental Risk Research
来源：
Archives of Toxicology | 2020年 / 94卷
关键词：
Arsenic; Metalloid; Methylation; Reduction; Arsine; Glutathione; Promyelocytic leukemia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Arsenic is a well-known environmental carcinogen and chronic exposure to arsenic through drinking water has been reported to cause skin, bladder and lung cancers, with arsenic metabolites being implicated in the pathogenesis. In contrast, arsenic trioxide (As2O3) is an effective therapeutic agent for the treatment of acute promyelocytic leukemia, in which the binding of arsenite (iAsIII) to promyelocytic leukemia (PML) protein is the proposed initial step. These findings on the two-edged sword characteristics of arsenic suggest that after entry into cells, arsenic reaches the nucleus and triggers various nuclear events. Arsenic is reduced, conjugated with glutathione, and methylated in the cytosol. These biotransformations, including the production of reactive metabolic intermediates, appear to determine the intracellular dynamics, target organs, and biological functions of arsenic.
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页码：2587 / 2601
页数：14
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