A convenient method for the synthesis of phosphoramidite non-nucleotide inserts for preparation of functionalized oligonucleotides

被引：0
|
作者：
M. S. Kupryushkin
D. V. Pyshnyi
机构：
[1] Siberian Branch of the Russian Academy of Sciences,Institute of Chemical Biology and Fundamental Medicine
来源：
Russian Journal of Bioorganic Chemistry | 2012年 / 38卷
关键词：
branched DNA; non-nucleotide insert; modified oligonucleotides; fluorescent probes; thermal stability;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A simple approach to the synthesis of amidophosphite synthons of achiral non-nucleotide inserts using 4-(2-(4,4′-dimethoxytrityloxy)ethyl)morpholine-2,3-dione as a backbone of key precursor was suggested. Non-nucleotide synthons were synthesized using this approach that were suitable for synthesis of acridine-containing oligonucleotide derivatives, as well as oligonucleotides with branched carbohydrate-phosphate backbone.
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页码：662 / 666
页数：4
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