Helicobacter pylori Genetic Diversity and Gastro-duodenal Diseases in Malaysia

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作者：
Selva Perumal Gunaletchumy
Indran Seevasant
Mun Hua Tan
Laurence J. Croft
Hazel M. Mitchell
Khean Lee Goh
Mun Fai Loke
Jamuna Vadivelu
机构：
[1] Faculty of Medicine,Department of Medical Microbiology
[2] University of Malaya,Department of Medicine
[3] Malaysian Genomics Resource Centre Berhad,undefined
[4] School of Biotechnology and Biomolecular Sciences,undefined
[5] University of New South Wales,undefined
[6] Faculty of Medicine,undefined
[7] University of Malaya,undefined
来源：
Scientific Reports | / 4卷
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摘要：
Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.
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