Association of gene polymorphisms in prolactin and its receptor with breast cancer risk in Taiwanese women

被引：0
作者：
Fan-Yun Mong
Yu-Liang Kuo
Ching-Wen Liu
Wen-Sheng Liu
Li-Ching Chang
机构：
[1] ZuoYing Armed Forces General Hospital,Division of General Surgery, Department of Surgery
[2] Chung Shan Medical University,School of Medical Imaging and Radiological Sciences
[3] Chung Shan Medical University Hospital,Department of Medical Imaging
[4] I-Shou University,Institute of Biotechnology and Chemical Engineering
[5] Asia-Pacific Biotech Developing,Department of Occupational Therapy
[6] Inc.,undefined
[7] I-Shou University,undefined
来源：
Molecular Biology Reports | 2011年 / 38卷
关键词：
Prolactin; Prolactin receptor; SNP; Breast cancer;
D O I：
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中图分类号：
学科分类号：
摘要：
Given the essential role of prolactin (PRL) and its receptor (PRLR) in breast tumorigenesis, we investigated whether single nucleotide polymorphisms (SNPs) in the PRL and PRLR genes were associated with breast cancer in Taiwanese women. A total of 160 breast cancer patients and 336 unrelated control Taiwanese women were enrolled in this study. Three SNPs (rs1341238, rs2244502 and rs3756824) in the PRL gene and one SNP (rs10941235) in the PRLR gene were genotyped using allele-specific polymerase chain reaction and DNA sequencing. We showed that the PRLR SNP rs10941235 was associated with breast cancer (P < 0.05) and its genotype frequencies in the breast cancer group were significantly associated (P < 0.05) with the levels of cancer antigen 15-3, a serum biomarker of breast cancer. The PRL SNP rs3756824 was significantly associated with breast cancer metastasis (P < 0.05). These findings suggest that the polymorphism rs10941235 in the PRLR gene is associated with breast cancer and cancer antigen 15-3 levels in Taiwanese women.
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页码：4629 / 4636
页数：7
相关论文
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