Analgesic and anti-inflammatory activity of b-sitosterol isolated from nyctanthes arbortristis leaves

被引：90
作者：
Sunil A. Nirmal
Subodh C. Pal
Subhash C. Mandal
Anuja N. Patil
机构：
[1] Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra
[2] Department of Pharmacognosy, NDMVPs College of Pharmacy, Nasik, Maharashtra
[3] Department of Pharmaceutical Technology, Pharmacognosy and Phytochemistry Research Laboratory, Jadavpur University, Kolkata
来源：
Inflammopharmacology | 2012年 / 20卷 / 4期
关键词：
Anti-inflammatory; B-Sitosterol; Nyctanthes arbortristis Linn;
D O I：
10.1007/s10787-011-0110-8
中图分类号：
学科分类号：
摘要：
Nyctanthes arbortristis Linn. (Oleaceae) is one of the well-known Indian medicinal plant. Various extracts of leaves of the plant were screened for analgesic activity by hot plate test and acetic acid-induced writhings and antiinflammatory activity by carrageenan-induced hind paw edema method at the dose of 50 mg/kg, i.p. Petroleum ether extract was found to be most active and hence subjected to activity-guided fractionation. Results showed that b-sitosterol (5, 10 and 20 mg/kg, i.p.) was responsible for the significant and dose-dependent activity comparable with the standard extract. b-Sitosterol from N. arbortristis leaves might be responsible for analgesic and anti-inflammatory activity. Analgesic. © Springer Basel AG 2011.
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页码：219 / 224
页数：5
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