Inostamycin suppresses vascular endothelial growth factor-stimulated growth and migration of human umbilical vein endothelial cells

被引：0
作者：
Yuh Baba
Yasumasa Kato
Izumi Mochimatsu
Yoji Nagashima
Miki Kurihara
Toshiro Kawano
Takahide Taguchi
Ryu-Ichiro Hata
Mamoru Tsukuda
机构：
[1] Yokohama City University Graduate School of Medicine,Department of Biology and Function in the Head and Neck
[2] Yokohama City University Graduate School of Medicine,Division of Molecular Pathology and Oncology
[3] Kanagawa Dental College,Department of Biochemistry and Molecular Biology
来源：
Clinical & Experimental Metastasis | 2004年 / 21卷
关键词：
Inostamycin; HUVECs; VEGF; proliferation; migration; MAPKs; cyclin D1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Angiogenesis involves multiple steps including proliferation and migration of endothelial cells. In the present study, we determined the effect of inostamycin (an inhibitor of phosphatidylinositol synthesis) on vascular endothelial growth factor (VEGF)-induced proliferation and migration of human umbilical vein endothelial cells (HUVECs). Inostamycin significantly attenuated both VEGF-induced proliferation and migration of HUVECs. Inostamycin inhibited activation of mitogen-activated kinases (ERK and p38) and elevation of cyclin D1 induced by VEGF. These data suggest that inostamycin reduced both proliferation and migration of HUVECs by targeting ERK-cyclin D1 and p38, respectively.
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页码：419 / 425
页数：6
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