Enterovirus 71 2C Protein Inhibits NF-κB Activation by Binding to RelA(p65)

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作者：
Haiwei Du
Peiqi Yin
Xiaojie Yang
Leiliang Zhang
Qi Jin
Guofeng Zhu
机构：
[1] Chinese Academy of Medical Sciences & Peking Union Medical College,MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology
[2] Shanghai Municipal Center for Disease Control & Prevention,undefined
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Scientific Reports | / 5卷
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摘要：
Viruses evolve multiple ways to interfere with NF-κB signaling, a key regulator of innate and adaptive immunity. Enterovirus 71 (EV71) is one of primary pathogens that cause hand-foot-mouth disease. Here, we identify RelA(p65) as a novel binding partner for EV71 2C protein from yeast two-hybrid screen. By interaction with IPT domain of p65, 2C reduces the formation of heterodimer p65/p50, the predominant form of NF-κB. We also show that picornavirus 2C family proteins inhibit NF-κB activation and associate with p65 and IKKβ. Our findings provide a novel mechanism how EV71 antagonizes innate immunity.
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