Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder: a voxel-based morphometry study

被引：0

作者：

Yi Cai

Jun Liu

Li Zhang

Mei Liao

Yan Zhang

Lifeng Wang

Hongjun Peng

Zhong He

Zexuan Li

Weihui Li

Shaojia Lu

Yuqiang Ding

Lingjiang Li

机构：

[1] Central South University,Mental Health Institute of the Second Xiangya Hospital, National Technology Institute of Psychiatry Key Laboratory of Psychiatry and Mental Health of Hunan Province

[2] the Second Xiangya Hospital of Central South University,Department of Radiology

[3] Brain Hospital of Hunan Province,Department of Mental Health and Psychiatry

[4] Hunan University of Chinese Medicine Clinical Medical College,Guangzhou Psychiatric Hospital

[5] Affiliated Hospital of Guangzhou Medical College,Key Laboratory of Arrhythmias, Ministry of Education, East Hospital

[6] Tongji University School of Medicine,undefined

[7] Shenzhen Kangning Hospital of Guangdong Province,undefined

来源：

Neuroscience Bulletin | 2015年 / 31卷

关键词：

bipolar depressive disorder; unipolar depressive disorder; prefrontal cortex; cingulate gyrus; voxel-based morphometry;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Bipolar disorder and unipolar depressive disorder (UD) may be different in brain structure. In the present study, we performed voxel-based morphometry (VBM) to quantify the grey matter volumes in 23 patients with bipolar I depressive disorder (BP1) and 23 patients with UD, and 23 age-, gender-, and education-matched healthy controls (HCs) using magnetic resonance imaging. We found that compared with the HC and UD groups, the BP1 group showed reduced grey matter volumes in the right inferior frontal gyrus and middle cingulate gyrus, while the UD group showed reduced volume in the right inferior frontal gyrus compared to HCs. In addition, correlation analyses revealed that the grey matter volumes of these regions were negatively correlated with the Hamilton depression rating scores. Taken together, the results of our study suggest that decreased grey matter volume of the right inferior frontal gyrus is a common abnormality in BP1 and UD, and decreased grey matter volume in the right middle cingulate gyrus may be specific to BP1.

引用

页码：4 / 12

页数：8

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