Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

被引：0
作者：
Jing J. [1 ]
Wang D. [2 ]
Jiao Y. [3 ]
Wang X. [2 ]
Wen H. [4 ]
Lin R. [4 ]
Jin J. [2 ]
Jin L. [2 ]
机构：
[1] Department of Biology, School of Environment and Chemical Engineering, Luoyang University
[2] Institute of Genetics, School of Life Sciences, Fudan University
[3] Department of Biochemical and Molecular Biology, Xinjiang Medical University
[4] Central Laboratory, Xinjiang Medical University
来源：
Frontiers of Medicine in China | 2007年 / 1卷 / 2期
关键词：
G protein; Hypertension; Polymorphism; Uygur;
D O I：
10.1007/s11684-007-0045-z
中图分类号：
学科分类号：
摘要：
The relationship between the tenth exon C825T of G-protein β 3 subunit (GNB3) genetic polymorphism and hypertension in the Uygur population of China was investigated. A nested case-control study (n = 738) was carried out. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotype GNB3 C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects. The distributions of GNB3 C825T genotypes were CC (27.2%), TT (42.9%), and CT (29.9%) in the hypertensive subjects and CC (27.7%), TT (42.4%), CT (29.9%) in the normotensive subjects. There were no significant differences in the genotype distributions between the two groups (χ2 = 0.0262 P = 0.99). The T allele was 51.4% in hypertensive subjects and 51.2% in normotensive subjects, which, between the two groups, was not a significant difference (χ2 = 0.0016 P = 0.97). Further analysis shows that there is no association between C825T genotypes and age, body mass index (BMI), Glucose (GLU), Triglyceride (TG), Cholesterol (CHO), systolic blood pressure (SBP) and diastolic blood pressure (DBP). No evidence was found to suggest an association between GNB3 C825T polymorphism and hypertension in the Uygur population of China. © Higher Education Press and Springer-Verlag 2007.
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页码：230 / 233
页数：3
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