Differential diagnosis of eosinophilic chronic rhinosinusitis

被引：0
作者：
John C. Sok
Berrylin J. Ferguson
机构：
[1] University of Pittsburgh School of Medicine,Department of Otolaryngology
来源：
Current Allergy and Asthma Reports | 2006年 / 6卷
关键词：
Eosinophilia; Allergy Clin Immunol; Nasal Polyp; Omalizumab; Chronic Rhinosinusitis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflammation. The provisional subcategories of ECRS include superantigen-induced eosinophilic chronic rhinosinusitis, allergic fungal sinusitis, nonallergic fungal eosinophilic chronic rhinosinusitis, and aspirin-exacerbated eosinophilic chronic rhinosinusitis. Within each subcategory, recent findings supporting distinct mechanisms that promote eosinophilic infiltration are presented, and, therefore, targeted therapeutic interventions with specific antibacterial, antifungal, or immune modulation may be indicated.
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页码：203 / 214
页数：11
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